World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.
Bottom Line: An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries.A postsurgical scoring sheet containing general and gynecological patient and procedural information, extent of disease, the location and type of endometriotic lesion, and any other findings was developed during several rounds of review.This is the first multicenter, international collaboration between academic centers and industry addressing standardization of phenotypic data collection for a specific disease.
Affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom; Endometriosis CaRe Centre Oxford, University of Oxford, Oxford, United Kingdom. Electronic address: email@example.com.Show MeSH
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Mentions: Where permitted and feasible, video recording of pelvic explorations and the actual surgical procedure should be considered (29). In addition, photo documentation is strongly encouraged and considered to be the standard recommended for research purposes, which will provide an objective record of the reported data. Also, it should be considered that while it is understood that there is interest in exploring the gross and molecular phenotype of individual lesions, it may be that unique and critical information can be discovered from the colony/cluster/microenvironment of lesions proximal to each other. These phenotypic details can only be documented and quantified from video and/or photographic evidence. Figure 2 shows the photo documentation to be collected as the standard recommended by the EPHect Working Group. The pelvis is divided into six zones, two in the midline and two for each side (Table 2). To capture each zone, a distance of 5–10 cm of the laparoscope to the peritoneal surface will be required. As most endometriotic disease is found in the pelvis, this distribution will include most of endometriotic lesions. If very small lesions are present, then it is important to capture them, if necessary with an additional, close-range picture (26, 30). Efforts should be made to photo and/or video document any other endometriotic sites outside the pelvis. A photograph of the pelvic cavity at the end of surgery, with particular focus on capturing any residual disease, should be included in the standard visual documentation.
Affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom; Endometriosis CaRe Centre Oxford, University of Oxford, Oxford, United Kingdom. Electronic address: firstname.lastname@example.org.