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Cutaneous involvement as the initial presentation of metastatic breast adenocarcinoma - Case report.

Siqueira VR, Frota AS, Maia IL, Queiroz HM, Valença Júnior JT, Accioly Filho JW - An Bras Dermatol (2014 Nov-Dec)

Bottom Line: It occurs late in the course of the disease but can be a sign of an unknown neoplasm.A case of local cutaneous metastasis by contiguity with breast adenocarcinoma is reported.It presented as initial manifestation and main complaint of a 68-year-old woman, with no family history and negative screening tests for the disease.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Ceará, Fortaleza, CE, Brazil.

ABSTRACT
Cutaneous metastasis is an uncommon manifestation of visceral malignancy. It occurs late in the course of the disease but can be a sign of an unknown neoplasm. A case of local cutaneous metastasis by contiguity with breast adenocarcinoma is reported. It presented as initial manifestation and main complaint of a 68-year-old woman, with no family history and negative screening tests for the disease. Biopsies of ulcers which do not heal, persistent hardened erythema and cutaneous nodules of unknown cause must be performed, since the evidence of cutaneous metastasis can be of extreme importance for the diagnosis, staging and prognosis of an internal cancer. In this scenario, the dermatologist plays a fundamental role and should be always attentive to this diagnostic possibility.

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Immunohistochemist ry of cutaneous lesion showing diffuse positivity for estrogenreceptors (ER), progesterone receptors (PR), cytokeratin 7 (CK7) and Mammoglobulin(Mammo)
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f05: Immunohistochemist ry of cutaneous lesion showing diffuse positivity for estrogenreceptors (ER), progesterone receptors (PR), cytokeratin 7 (CK7) and Mammoglobulin(Mammo)

Mentions: Histopathologic examination of the cutaneous lesion revealed epidermis with noalterations. The dermis exhibited proliferation in blocks of atypical cells in a solidsetting, other times similar to glands, irregular, with moderate nuclear pleomorphismand intense desmoplasia, compatible with poorly differentiated adenocarcinoma (Figures 3 and 4). Immunochemistry revealed diffuse positivity (+++) in 90% of the neoplasticcells for estrogen receptors (ERs) and progesterone receptors (PRs), besides diffusepositivity for AE1/AE3, CK7 and mammoglobulin, focal positivity for 34bE12 andnegativity for CDX 2 and TTF-1, being this immunohistochemical profile compatible withcutaneous infiltration by primary mammary adenocarcinoma (Figure 5).


Cutaneous involvement as the initial presentation of metastatic breast adenocarcinoma - Case report.

Siqueira VR, Frota AS, Maia IL, Queiroz HM, Valença Júnior JT, Accioly Filho JW - An Bras Dermatol (2014 Nov-Dec)

Immunohistochemist ry of cutaneous lesion showing diffuse positivity for estrogenreceptors (ER), progesterone receptors (PR), cytokeratin 7 (CK7) and Mammoglobulin(Mammo)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230665&req=5

f05: Immunohistochemist ry of cutaneous lesion showing diffuse positivity for estrogenreceptors (ER), progesterone receptors (PR), cytokeratin 7 (CK7) and Mammoglobulin(Mammo)
Mentions: Histopathologic examination of the cutaneous lesion revealed epidermis with noalterations. The dermis exhibited proliferation in blocks of atypical cells in a solidsetting, other times similar to glands, irregular, with moderate nuclear pleomorphismand intense desmoplasia, compatible with poorly differentiated adenocarcinoma (Figures 3 and 4). Immunochemistry revealed diffuse positivity (+++) in 90% of the neoplasticcells for estrogen receptors (ERs) and progesterone receptors (PRs), besides diffusepositivity for AE1/AE3, CK7 and mammoglobulin, focal positivity for 34bE12 andnegativity for CDX 2 and TTF-1, being this immunohistochemical profile compatible withcutaneous infiltration by primary mammary adenocarcinoma (Figure 5).

Bottom Line: It occurs late in the course of the disease but can be a sign of an unknown neoplasm.A case of local cutaneous metastasis by contiguity with breast adenocarcinoma is reported.It presented as initial manifestation and main complaint of a 68-year-old woman, with no family history and negative screening tests for the disease.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Ceará, Fortaleza, CE, Brazil.

ABSTRACT
Cutaneous metastasis is an uncommon manifestation of visceral malignancy. It occurs late in the course of the disease but can be a sign of an unknown neoplasm. A case of local cutaneous metastasis by contiguity with breast adenocarcinoma is reported. It presented as initial manifestation and main complaint of a 68-year-old woman, with no family history and negative screening tests for the disease. Biopsies of ulcers which do not heal, persistent hardened erythema and cutaneous nodules of unknown cause must be performed, since the evidence of cutaneous metastasis can be of extreme importance for the diagnosis, staging and prognosis of an internal cancer. In this scenario, the dermatologist plays a fundamental role and should be always attentive to this diagnostic possibility.

Show MeSH
Related in: MedlinePlus