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Update on cutaneous tuberculosis.

Dias MF, Bernardes Filho F, Quaresma MV, Nascimento LV, Nery JA, Azulay DR - An Bras Dermatol (2014 Nov-Dec)

Bottom Line: Cutaneous tuberculosis is an infection caused by M. tuberculosis complex, M. bovis and bacillus Calmette-Guérin.Depending on individual immunity, environmental factors and the type of inoculum, it may present varied clinical and evolutionary aspects.Patients with HIV and those using immunobiological drugs are more prone to infection, which is a great concern in centers where the disease is considered endemic.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA-SCMRJ), Rio de Janeiro, RJ, Brazil.

ABSTRACT
Tuberculosis continues to draw special attention from health care professionals and society in general. Cutaneous tuberculosis is an infection caused by M. tuberculosis complex, M. bovis and bacillus Calmette-Guérin. Depending on individual immunity, environmental factors and the type of inoculum, it may present varied clinical and evolutionary aspects. Patients with HIV and those using immunobiological drugs are more prone to infection, which is a great concern in centers where the disease is considered endemic. This paper aims to review the current situation of cutaneous tuberculosis in light of this new scenario, highlighting the emergence of new and more specific methods of diagnosis, and the molecular and cellular mechanisms that regulate the parasite-host interaction.

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Related in: MedlinePlus

A. Tuberculosis verrucosa – verrucous plaque with scaling located onthe right axilla; B. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); C. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); D. Lupus vulgaris – erythematous infiltrating plaque withcrusts located on the buttocks
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f01: A. Tuberculosis verrucosa – verrucous plaque with scaling located onthe right axilla; B. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); C. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); D. Lupus vulgaris – erythematous infiltrating plaque withcrusts located on the buttocks

Mentions: It appears as painless, isolated or multiple verrucous and tuberous papules, of slowevolution and spontaneous involution, without adenopathy, usually located on theextremities. Its most frequent location is on the hands and it results from exogenousinoculation (Figure 1A). It can be considered anoccupational disease, due to self-inoculation possibilities, such as may occur to adentist treating the mouth of a patient with pulmonary TB or to a butcher handlingcontaminated meat (in the latter case it is usually due to infection by M.bovis). PPD test is strongly positive.2,16,60,66,67


Update on cutaneous tuberculosis.

Dias MF, Bernardes Filho F, Quaresma MV, Nascimento LV, Nery JA, Azulay DR - An Bras Dermatol (2014 Nov-Dec)

A. Tuberculosis verrucosa – verrucous plaque with scaling located onthe right axilla; B. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); C. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); D. Lupus vulgaris – erythematous infiltrating plaque withcrusts located on the buttocks
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230662&req=5

f01: A. Tuberculosis verrucosa – verrucous plaque with scaling located onthe right axilla; B. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); C. Lupus vulgaris (Courtesy from Dr. Marcelo Lyra -Fiocruz); D. Lupus vulgaris – erythematous infiltrating plaque withcrusts located on the buttocks
Mentions: It appears as painless, isolated or multiple verrucous and tuberous papules, of slowevolution and spontaneous involution, without adenopathy, usually located on theextremities. Its most frequent location is on the hands and it results from exogenousinoculation (Figure 1A). It can be considered anoccupational disease, due to self-inoculation possibilities, such as may occur to adentist treating the mouth of a patient with pulmonary TB or to a butcher handlingcontaminated meat (in the latter case it is usually due to infection by M.bovis). PPD test is strongly positive.2,16,60,66,67

Bottom Line: Cutaneous tuberculosis is an infection caused by M. tuberculosis complex, M. bovis and bacillus Calmette-Guérin.Depending on individual immunity, environmental factors and the type of inoculum, it may present varied clinical and evolutionary aspects.Patients with HIV and those using immunobiological drugs are more prone to infection, which is a great concern in centers where the disease is considered endemic.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA-SCMRJ), Rio de Janeiro, RJ, Brazil.

ABSTRACT
Tuberculosis continues to draw special attention from health care professionals and society in general. Cutaneous tuberculosis is an infection caused by M. tuberculosis complex, M. bovis and bacillus Calmette-Guérin. Depending on individual immunity, environmental factors and the type of inoculum, it may present varied clinical and evolutionary aspects. Patients with HIV and those using immunobiological drugs are more prone to infection, which is a great concern in centers where the disease is considered endemic. This paper aims to review the current situation of cutaneous tuberculosis in light of this new scenario, highlighting the emergence of new and more specific methods of diagnosis, and the molecular and cellular mechanisms that regulate the parasite-host interaction.

Show MeSH
Related in: MedlinePlus