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Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.

Koride S, He L, Xiong LP, Lan G, Montell DJ, Sun SX - Mol. Biol. Cell (2014)

Bottom Line: We propose that follicle cells in the epithelial layer contract against pressure in the expanding egg chamber.The activation process is cooperative, leading to a limit cycle in the myosin dynamics.The model demonstrates that in principle, mechanochemical interactions are sufficient to drive patterning and morphogenesis, independent of patterned gene expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.

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Internal egg chamber pressure and maximum contractile force have opposing effects on egg chamber radius. (A) Plot showing change in egg chamber radius as a function of internal pressure (P). Increase in pressure increases the egg chamber radius (here Fmax = 40nN per unit-cell width). (B) Plot showing change in egg chamber radius as a function of maximum contractile force Fmax. Increase in Fmax decreases the egg chamber radius (here P = 0.4 kPa).
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Figure 4: Internal egg chamber pressure and maximum contractile force have opposing effects on egg chamber radius. (A) Plot showing change in egg chamber radius as a function of internal pressure (P). Increase in pressure increases the egg chamber radius (here Fmax = 40nN per unit-cell width). (B) Plot showing change in egg chamber radius as a function of maximum contractile force Fmax. Increase in Fmax decreases the egg chamber radius (here P = 0.4 kPa).

Mentions: Computations show that frequency and amplitude of cell oscillations, as well as the egg chamber radius and mean myosin intensity, all depend on Fmax and P (Supplemental Figures S6 and S7). In particular, the egg chamber radius decreases with increase in the maximum contractile force Fmax and increases with increase in internal egg chamber pressure P (Figure 4). Oscillation period follows a decreasing trend with increase in Fmax. For some para­meter regimes, synchronized oscillations are also seen. We estimate that physiologically relevant parameters are close to Fmax = 50 nN and P = 0.3 kPa.


Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.

Koride S, He L, Xiong LP, Lan G, Montell DJ, Sun SX - Mol. Biol. Cell (2014)

Internal egg chamber pressure and maximum contractile force have opposing effects on egg chamber radius. (A) Plot showing change in egg chamber radius as a function of internal pressure (P). Increase in pressure increases the egg chamber radius (here Fmax = 40nN per unit-cell width). (B) Plot showing change in egg chamber radius as a function of maximum contractile force Fmax. Increase in Fmax decreases the egg chamber radius (here P = 0.4 kPa).
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Related In: Results  -  Collection

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Figure 4: Internal egg chamber pressure and maximum contractile force have opposing effects on egg chamber radius. (A) Plot showing change in egg chamber radius as a function of internal pressure (P). Increase in pressure increases the egg chamber radius (here Fmax = 40nN per unit-cell width). (B) Plot showing change in egg chamber radius as a function of maximum contractile force Fmax. Increase in Fmax decreases the egg chamber radius (here P = 0.4 kPa).
Mentions: Computations show that frequency and amplitude of cell oscillations, as well as the egg chamber radius and mean myosin intensity, all depend on Fmax and P (Supplemental Figures S6 and S7). In particular, the egg chamber radius decreases with increase in the maximum contractile force Fmax and increases with increase in internal egg chamber pressure P (Figure 4). Oscillation period follows a decreasing trend with increase in Fmax. For some para­meter regimes, synchronized oscillations are also seen. We estimate that physiologically relevant parameters are close to Fmax = 50 nN and P = 0.3 kPa.

Bottom Line: We propose that follicle cells in the epithelial layer contract against pressure in the expanding egg chamber.The activation process is cooperative, leading to a limit cycle in the myosin dynamics.The model demonstrates that in principle, mechanochemical interactions are sufficient to drive patterning and morphogenesis, independent of patterned gene expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.

Show MeSH
Related in: MedlinePlus