Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber.
Bottom Line: We propose that follicle cells in the epithelial layer contract against pressure in the expanding egg chamber.The activation process is cooperative, leading to a limit cycle in the myosin dynamics.The model demonstrates that in principle, mechanochemical interactions are sufficient to drive patterning and morphogenesis, independent of patterned gene expression.
Affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.Show MeSH
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Mentions: Computations show that frequency and amplitude of cell oscillations, as well as the egg chamber radius and mean myosin intensity, all depend on Fmax and P (Supplemental Figures S6 and S7). In particular, the egg chamber radius decreases with increase in the maximum contractile force Fmax and increases with increase in internal egg chamber pressure P (Figure 4). Oscillation period follows a decreasing trend with increase in Fmax. For some parameter regimes, synchronized oscillations are also seen. We estimate that physiologically relevant parameters are close to Fmax = 50 nN and P = 0.3 kPa.
Affiliation: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218.