Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons.
Bottom Line: Furthermore, we observed by quantitative imaging using fluorescence decay after photoactivation recordings of photoactivatable GFP-tagged tubulin that, despite this rapid dynamics, tau is capable of regulating the tubulin-microtubule balance.Our data imply a novel kiss-and-hop mechanism by which tau promotes neuronal microtubule assembly.The rapid kiss-and-hop interaction explains why tau, although binding to microtubules, does not interfere with axonal transport.
Affiliation: Department of Neurobiology, University of Osnabrück, D-49076 Osnabrück, Germany.Show MeSH
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Affiliation: Department of Neurobiology, University of Osnabrück, D-49076 Osnabrück, Germany.