Limits...
Emergent mechanics of biological structures.

Dumont S, Prakash M - Mol. Biol. Cell (2014)

Bottom Line: Unlike the engineered macroscopic structures that we commonly build, biological structures are dynamic and self-organize: they sculpt themselves and change their own architecture, and they have structural building blocks that generate force and constantly come on and off.A description of such structures defies current traditional mechanical frameworks.It requires approaches that account for active force-generating parts and for the formation of spatial and temporal patterns utilizing a diverse array of building blocks.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell and Tissue Biology and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143-0512 sophie.dumont@ucsf.edu.

Show MeSH
Challenges in emergent mechanics. Biological structures are dynamic and self-organize: their building blocks come on and off on their own, whole structures transform to take new shapes and functions, and their building blocks can consume energy and generate force. Not only do these structures interweave 1) temporal, 2) architectural, and 3) active force-generation dynamics, but they do so across length scales (from nanometers to meters) and time scales (from milliseconds to days). New theoretical frameworks and experimental approaches that integrate these three aspects will provide headway in understanding the emergent mechanics of biological structures.
© Copyright Policy - creative-commons
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4230603&req=5

Figure 1: Challenges in emergent mechanics. Biological structures are dynamic and self-organize: their building blocks come on and off on their own, whole structures transform to take new shapes and functions, and their building blocks can consume energy and generate force. Not only do these structures interweave 1) temporal, 2) architectural, and 3) active force-generation dynamics, but they do so across length scales (from nanometers to meters) and time scales (from milliseconds to days). New theoretical frameworks and experimental approaches that integrate these three aspects will provide headway in understanding the emergent mechanics of biological structures.

Mentions: Although these three challenges are significant, it is their combination that presents the grandest challenge to understanding emergent mechanics (Figure 1): temporal, architectural, and active force-generation dynamics all affect each other (feedback loops), raising the structure's complexity to a level that defies traditional frameworks and everyday intuition.


Emergent mechanics of biological structures.

Dumont S, Prakash M - Mol. Biol. Cell (2014)

Challenges in emergent mechanics. Biological structures are dynamic and self-organize: their building blocks come on and off on their own, whole structures transform to take new shapes and functions, and their building blocks can consume energy and generate force. Not only do these structures interweave 1) temporal, 2) architectural, and 3) active force-generation dynamics, but they do so across length scales (from nanometers to meters) and time scales (from milliseconds to days). New theoretical frameworks and experimental approaches that integrate these three aspects will provide headway in understanding the emergent mechanics of biological structures.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4230603&req=5

Figure 1: Challenges in emergent mechanics. Biological structures are dynamic and self-organize: their building blocks come on and off on their own, whole structures transform to take new shapes and functions, and their building blocks can consume energy and generate force. Not only do these structures interweave 1) temporal, 2) architectural, and 3) active force-generation dynamics, but they do so across length scales (from nanometers to meters) and time scales (from milliseconds to days). New theoretical frameworks and experimental approaches that integrate these three aspects will provide headway in understanding the emergent mechanics of biological structures.
Mentions: Although these three challenges are significant, it is their combination that presents the grandest challenge to understanding emergent mechanics (Figure 1): temporal, architectural, and active force-generation dynamics all affect each other (feedback loops), raising the structure's complexity to a level that defies traditional frameworks and everyday intuition.

Bottom Line: Unlike the engineered macroscopic structures that we commonly build, biological structures are dynamic and self-organize: they sculpt themselves and change their own architecture, and they have structural building blocks that generate force and constantly come on and off.A description of such structures defies current traditional mechanical frameworks.It requires approaches that account for active force-generating parts and for the formation of spatial and temporal patterns utilizing a diverse array of building blocks.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell and Tissue Biology and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143-0512 sophie.dumont@ucsf.edu.

Show MeSH