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Distant metastasis of rectal adenocarcinoma in a temporary tracheostoma.

Sifrer R, Strojan P, Zidar N, Zargi M, Groselj A, Krajinovic M - Radiol Oncol (2014)

Bottom Line: Fifty-four-year-old female patient, previously treated for a rectal adenocarcinoma, reported in our office with exophytic pink tissue masses around the temporary tracheostoma.The patient received palliative radiotherapy and died of systemic progression of the disease.The type of treatment depends on the extent of the disease, previous therapy and general condition of the patient.

View Article: PubMed Central - PubMed

Affiliation: University Department of Otorhinolaryngology and Head and Neck Surgery, Ljubljana, Slovenia.

ABSTRACT

Background: The temporary tracheostoma's metastases of head and neck cancer had already been reported in the literature. So far, they had been considered as regional dissemination of the malignant disease. We report a case of temporary tracheostoma's metastasis of carcinoma from non-head-and-neck primary site, what has not been reported in the literature, yet. Therefore, it is the first reported case of the systemic dissemination of malignant tumour into temporary tracheostoma.

Case report: Fifty-four-year-old female patient, previously treated for a rectal adenocarcinoma, reported in our office with exophytic pink tissue masses around the temporary tracheostoma. The biopsy and immunohistochemistry findings were consistent with temporary tracheostoma's metastasis of the rectal adenocarcinoma. The patient received palliative radiotherapy and died of systemic progression of the disease.

Conclusions: The patients with history of primary cancer of any origin and exophytic proliferating changes around the tracheostoma require an appropriate diagnostic work-up including a biopsy. The type of treatment depends on the extent of the disease, previous therapy and general condition of the patient.

No MeSH data available.


Related in: MedlinePlus

Adenocarcinoma metastatic to tracheostoma. A. Atypical tubular glandular structures with abundant necrosis, tumour cells show moderate cellular and nuclear polymorphism. B. Immunohistochemical reaction for cytokeratin 20 is strongly positive in tumour cells.
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f2-rado-48-04-393: Adenocarcinoma metastatic to tracheostoma. A. Atypical tubular glandular structures with abundant necrosis, tumour cells show moderate cellular and nuclear polymorphism. B. Immunohistochemical reaction for cytokeratin 20 is strongly positive in tumour cells.

Mentions: The biopsy sample measured 7 × 5 × 2 mm and consisted of a tumour with abundant necrosis. Histologically, the tumour was composed of atypical glandular tubular structures and islands of tumour cells exhibiting moderate cellular and nuclear pleomorphism, and numerous mitotic figures (Figure 2A). Immunohistochemical analyses showed a diffusely positive reaction for cytokeratin 20 (Figure 2B), and a negative reaction for cytokeratin 7. Morphologic characteristics and the immunophenotypes of the tumour samples from the tracheostoma and the colon were similar, confirming the diagnosis of colon adenocarcinoma metastatic to tracheostoma.


Distant metastasis of rectal adenocarcinoma in a temporary tracheostoma.

Sifrer R, Strojan P, Zidar N, Zargi M, Groselj A, Krajinovic M - Radiol Oncol (2014)

Adenocarcinoma metastatic to tracheostoma. A. Atypical tubular glandular structures with abundant necrosis, tumour cells show moderate cellular and nuclear polymorphism. B. Immunohistochemical reaction for cytokeratin 20 is strongly positive in tumour cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230560&req=5

f2-rado-48-04-393: Adenocarcinoma metastatic to tracheostoma. A. Atypical tubular glandular structures with abundant necrosis, tumour cells show moderate cellular and nuclear polymorphism. B. Immunohistochemical reaction for cytokeratin 20 is strongly positive in tumour cells.
Mentions: The biopsy sample measured 7 × 5 × 2 mm and consisted of a tumour with abundant necrosis. Histologically, the tumour was composed of atypical glandular tubular structures and islands of tumour cells exhibiting moderate cellular and nuclear pleomorphism, and numerous mitotic figures (Figure 2A). Immunohistochemical analyses showed a diffusely positive reaction for cytokeratin 20 (Figure 2B), and a negative reaction for cytokeratin 7. Morphologic characteristics and the immunophenotypes of the tumour samples from the tracheostoma and the colon were similar, confirming the diagnosis of colon adenocarcinoma metastatic to tracheostoma.

Bottom Line: Fifty-four-year-old female patient, previously treated for a rectal adenocarcinoma, reported in our office with exophytic pink tissue masses around the temporary tracheostoma.The patient received palliative radiotherapy and died of systemic progression of the disease.The type of treatment depends on the extent of the disease, previous therapy and general condition of the patient.

View Article: PubMed Central - PubMed

Affiliation: University Department of Otorhinolaryngology and Head and Neck Surgery, Ljubljana, Slovenia.

ABSTRACT

Background: The temporary tracheostoma's metastases of head and neck cancer had already been reported in the literature. So far, they had been considered as regional dissemination of the malignant disease. We report a case of temporary tracheostoma's metastasis of carcinoma from non-head-and-neck primary site, what has not been reported in the literature, yet. Therefore, it is the first reported case of the systemic dissemination of malignant tumour into temporary tracheostoma.

Case report: Fifty-four-year-old female patient, previously treated for a rectal adenocarcinoma, reported in our office with exophytic pink tissue masses around the temporary tracheostoma. The biopsy and immunohistochemistry findings were consistent with temporary tracheostoma's metastasis of the rectal adenocarcinoma. The patient received palliative radiotherapy and died of systemic progression of the disease.

Conclusions: The patients with history of primary cancer of any origin and exophytic proliferating changes around the tracheostoma require an appropriate diagnostic work-up including a biopsy. The type of treatment depends on the extent of the disease, previous therapy and general condition of the patient.

No MeSH data available.


Related in: MedlinePlus