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The role of elastosonography, gray-scale and colour flow Doppler sonography in prediction of malignancy in thyroid nodules.

Tatar IG, Kurt A, Yilmaz KB, Doğan M, Hekimoglu B, Hucumenoglu S - Radiol Oncol (2014)

Bottom Line: Most of the benign nodules had score 2 and 3, none of them displayed score 5.On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Ankara Diskapı Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Background: Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy.

Patients and methods: 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules were benign and 9 were malignant.

Results: Orientation of the nodule was the only sonographic parameter associated with malignancy (p = 0.003). In the strain ratio analysis the best cut-off point was 1.935 to discriminate malignancy (p = 0.000), with 100% sensitivity, 76% specificity, 100% negative predictive value, 78.5% positive predictive value and 78% accuracy rate. There was a statistically significant correlation between the elasticity score and malignancy (p = 0.001). Most of the benign nodules had score 2 and 3, none of them displayed score 5. On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.

Conclusions: A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

No MeSH data available.


Related in: MedlinePlus

A Elastosonographic evaluation of an isoechoic solid nodule measuring 6.7 × 5.4 mm with well-defined margins, parallel orientation and peripheral halo in the right lobe of the thyroid gland of a 44 year-old female patient. Region of interest of the nodule is represented by A, region of interest of the adjacent thyroid parenchyme is represented by B. Elasticity score interpretation was 2, strain ratio measurement was 1.56. B Fine needle aspiration cytology revealed benign thyrocyte group forming low cellularity macrofollicule formation (May-Grunwald giemsa stain, X200).
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f3-rado-48-04-348: A Elastosonographic evaluation of an isoechoic solid nodule measuring 6.7 × 5.4 mm with well-defined margins, parallel orientation and peripheral halo in the right lobe of the thyroid gland of a 44 year-old female patient. Region of interest of the nodule is represented by A, region of interest of the adjacent thyroid parenchyme is represented by B. Elasticity score interpretation was 2, strain ratio measurement was 1.56. B Fine needle aspiration cytology revealed benign thyrocyte group forming low cellularity macrofollicule formation (May-Grunwald giemsa stain, X200).

Mentions: There was a statistically significant correlation between the ES and cytology of the nodules (p = 0.001). When the elasticity scores of the benign nodules were analysed most of the benign nodules had ES 2 and 3. Among the benign nodules 2 nodules displayed ES 1 (1.4%); 69 nodules showed ES 2 (48.9%) (Figure 3); 56 nodules had ES 3 (39.7%) and 14 nodules revealed ES 4 (9.9%). None of the benign nodules displayed ES 5. On the other hand, none of the malignant nodules had ES 1 and 2, most of them displaying an ES 5. Among the malignant nodules 2 nodules displayed ES 3 (22.2%); 3 nodules had ES 4 (33.3%) (Figure 4); 4 nodules showed ES 5 (44.4%).


The role of elastosonography, gray-scale and colour flow Doppler sonography in prediction of malignancy in thyroid nodules.

Tatar IG, Kurt A, Yilmaz KB, Doğan M, Hekimoglu B, Hucumenoglu S - Radiol Oncol (2014)

A Elastosonographic evaluation of an isoechoic solid nodule measuring 6.7 × 5.4 mm with well-defined margins, parallel orientation and peripheral halo in the right lobe of the thyroid gland of a 44 year-old female patient. Region of interest of the nodule is represented by A, region of interest of the adjacent thyroid parenchyme is represented by B. Elasticity score interpretation was 2, strain ratio measurement was 1.56. B Fine needle aspiration cytology revealed benign thyrocyte group forming low cellularity macrofollicule formation (May-Grunwald giemsa stain, X200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230554&req=5

f3-rado-48-04-348: A Elastosonographic evaluation of an isoechoic solid nodule measuring 6.7 × 5.4 mm with well-defined margins, parallel orientation and peripheral halo in the right lobe of the thyroid gland of a 44 year-old female patient. Region of interest of the nodule is represented by A, region of interest of the adjacent thyroid parenchyme is represented by B. Elasticity score interpretation was 2, strain ratio measurement was 1.56. B Fine needle aspiration cytology revealed benign thyrocyte group forming low cellularity macrofollicule formation (May-Grunwald giemsa stain, X200).
Mentions: There was a statistically significant correlation between the ES and cytology of the nodules (p = 0.001). When the elasticity scores of the benign nodules were analysed most of the benign nodules had ES 2 and 3. Among the benign nodules 2 nodules displayed ES 1 (1.4%); 69 nodules showed ES 2 (48.9%) (Figure 3); 56 nodules had ES 3 (39.7%) and 14 nodules revealed ES 4 (9.9%). None of the benign nodules displayed ES 5. On the other hand, none of the malignant nodules had ES 1 and 2, most of them displaying an ES 5. Among the malignant nodules 2 nodules displayed ES 3 (22.2%); 3 nodules had ES 4 (33.3%) (Figure 4); 4 nodules showed ES 5 (44.4%).

Bottom Line: Most of the benign nodules had score 2 and 3, none of them displayed score 5.On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Ankara Diskapı Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Background: Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy.

Patients and methods: 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules were benign and 9 were malignant.

Results: Orientation of the nodule was the only sonographic parameter associated with malignancy (p = 0.003). In the strain ratio analysis the best cut-off point was 1.935 to discriminate malignancy (p = 0.000), with 100% sensitivity, 76% specificity, 100% negative predictive value, 78.5% positive predictive value and 78% accuracy rate. There was a statistically significant correlation between the elasticity score and malignancy (p = 0.001). Most of the benign nodules had score 2 and 3, none of them displayed score 5. On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.

Conclusions: A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

No MeSH data available.


Related in: MedlinePlus