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The role of elastosonography, gray-scale and colour flow Doppler sonography in prediction of malignancy in thyroid nodules.

Tatar IG, Kurt A, Yilmaz KB, Doğan M, Hekimoglu B, Hucumenoglu S - Radiol Oncol (2014)

Bottom Line: Most of the benign nodules had score 2 and 3, none of them displayed score 5.On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Ankara Diskapı Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Background: Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy.

Patients and methods: 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules were benign and 9 were malignant.

Results: Orientation of the nodule was the only sonographic parameter associated with malignancy (p = 0.003). In the strain ratio analysis the best cut-off point was 1.935 to discriminate malignancy (p = 0.000), with 100% sensitivity, 76% specificity, 100% negative predictive value, 78.5% positive predictive value and 78% accuracy rate. There was a statistically significant correlation between the elasticity score and malignancy (p = 0.001). Most of the benign nodules had score 2 and 3, none of them displayed score 5. On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.

Conclusions: A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

No MeSH data available.


Related in: MedlinePlus

Patients included in the study.
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f1-rado-48-04-348: Patients included in the study.

Mentions: In total 200 patients with thyroid nodules who were referred to the radiology department for FNAC by the general surgery department were assessed for eligibility. After obtaining the approval of the institutional ethical board committee, informed consent was taken from the participants. Seventeen patients refused to participate; furthermore, 13 patients with nodules having egg shell calcifications, >50% cystic component detected by US and thyroiditis, three patients with hematologic diseases and other comorbidities related with complications at the FNA were excluded from the study. From the remaining 167 patients 5 patients refused to undergo FNAC. The study sample included 162 patients (mean age 49 years; range, 20–83 years; 132 females and 30 males). Patients were examined by US and USE prior to FNAC. The patient flow of the study is summarized in Figure 1.


The role of elastosonography, gray-scale and colour flow Doppler sonography in prediction of malignancy in thyroid nodules.

Tatar IG, Kurt A, Yilmaz KB, Doğan M, Hekimoglu B, Hucumenoglu S - Radiol Oncol (2014)

Patients included in the study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230554&req=5

f1-rado-48-04-348: Patients included in the study.
Mentions: In total 200 patients with thyroid nodules who were referred to the radiology department for FNAC by the general surgery department were assessed for eligibility. After obtaining the approval of the institutional ethical board committee, informed consent was taken from the participants. Seventeen patients refused to participate; furthermore, 13 patients with nodules having egg shell calcifications, >50% cystic component detected by US and thyroiditis, three patients with hematologic diseases and other comorbidities related with complications at the FNA were excluded from the study. From the remaining 167 patients 5 patients refused to undergo FNAC. The study sample included 162 patients (mean age 49 years; range, 20–83 years; 132 females and 30 males). Patients were examined by US and USE prior to FNAC. The patient flow of the study is summarized in Figure 1.

Bottom Line: Most of the benign nodules had score 2 and 3, none of them displayed score 5.On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Ankara Diskapı Training and Research Hospital, Ankara, Turkey.

ABSTRACT

Background: Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy.

Patients and methods: 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules were benign and 9 were malignant.

Results: Orientation of the nodule was the only sonographic parameter associated with malignancy (p = 0.003). In the strain ratio analysis the best cut-off point was 1.935 to discriminate malignancy (p = 0.000), with 100% sensitivity, 76% specificity, 100% negative predictive value, 78.5% positive predictive value and 78% accuracy rate. There was a statistically significant correlation between the elasticity score and malignancy (p = 0.001). Most of the benign nodules had score 2 and 3, none of them displayed score 5. On the other hand, none of the malignant nodules had score 1 and 2, most of them displaying score 5.

Conclusions: A change in the diagnostic algorithm of the thyroid nodules should be considered integrating the elastosonographic analysis.

No MeSH data available.


Related in: MedlinePlus