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Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.

Hashmi AA, Faridi N, Edhi MM, Khan M - Int Arch Med (2014)

Bottom Line: The case was diagnosed as UTROSCT.No evidence of metastasis was found on systemic clinical and radiologic workup.UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.

ABSTRACT

Introduction: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.

Case presentation: A 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy. Gross examination revealed a gelatinous grayish white tumor confined to the myometrium, 7 cm in maximum dimention. Microscopic examination revealed monomorphic round to oval tumor cells in anastomosing cords and trabeculae with myxoid background. Immunohistochemically, tumor cells showed diffuse positivity for vimentin, CD99 and S100, while focal positivity was seen with pancytokeratin immunostain. The case was diagnosed as UTROSCT. No evidence of metastasis was found on systemic clinical and radiologic workup.

Conclusion: UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds. It is important to recognize these tumors as they behave differently from endometrial stromal tumors with sex cord like elements (ESTSCLE).

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical stains of UTROSCT. a: Vimentin showing diffuse strong positivity in tumor cells. b: CD99 revealing diffuse positivity in tumor cells. c: S100 immunostain with diffuse expression in tumor cells. d: Cytokeratin stain showing focal expression in tumor cells.
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Fig2: Immunohistochemical stains of UTROSCT. a: Vimentin showing diffuse strong positivity in tumor cells. b: CD99 revealing diffuse positivity in tumor cells. c: S100 immunostain with diffuse expression in tumor cells. d: Cytokeratin stain showing focal expression in tumor cells.

Mentions: Immunohistochemical stains were performed by DAKO envision method on a representation section of the tumor. Tumor cells showed diffuse positivity for vimentin (Figure 2a), CD99 (Figure 2b) and S100 (Figure 2c) stains. Focal positivity was noted with pancytokeratin immunostain (Figure 2d) and occasional cells showed desmin positivity. Negative stains include ASMA, CD10, EMA, CK7, CD31, Chromogranin A, HMB45, Melan A, Calretinin, PLAP and CD117 stains. Inhibin was also done which was found to be negative. The case was also consulted with extra-institutional senior pathologists and diagnosed as UTROSCT. There was no evidence of metastasis on systemic radiologic workup.Figure 1


Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.

Hashmi AA, Faridi N, Edhi MM, Khan M - Int Arch Med (2014)

Immunohistochemical stains of UTROSCT. a: Vimentin showing diffuse strong positivity in tumor cells. b: CD99 revealing diffuse positivity in tumor cells. c: S100 immunostain with diffuse expression in tumor cells. d: Cytokeratin stain showing focal expression in tumor cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230524&req=5

Fig2: Immunohistochemical stains of UTROSCT. a: Vimentin showing diffuse strong positivity in tumor cells. b: CD99 revealing diffuse positivity in tumor cells. c: S100 immunostain with diffuse expression in tumor cells. d: Cytokeratin stain showing focal expression in tumor cells.
Mentions: Immunohistochemical stains were performed by DAKO envision method on a representation section of the tumor. Tumor cells showed diffuse positivity for vimentin (Figure 2a), CD99 (Figure 2b) and S100 (Figure 2c) stains. Focal positivity was noted with pancytokeratin immunostain (Figure 2d) and occasional cells showed desmin positivity. Negative stains include ASMA, CD10, EMA, CK7, CD31, Chromogranin A, HMB45, Melan A, Calretinin, PLAP and CD117 stains. Inhibin was also done which was found to be negative. The case was also consulted with extra-institutional senior pathologists and diagnosed as UTROSCT. There was no evidence of metastasis on systemic radiologic workup.Figure 1

Bottom Line: The case was diagnosed as UTROSCT.No evidence of metastasis was found on systemic clinical and radiologic workup.UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.

ABSTRACT

Introduction: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.

Case presentation: A 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy. Gross examination revealed a gelatinous grayish white tumor confined to the myometrium, 7 cm in maximum dimention. Microscopic examination revealed monomorphic round to oval tumor cells in anastomosing cords and trabeculae with myxoid background. Immunohistochemically, tumor cells showed diffuse positivity for vimentin, CD99 and S100, while focal positivity was seen with pancytokeratin immunostain. The case was diagnosed as UTROSCT. No evidence of metastasis was found on systemic clinical and radiologic workup.

Conclusion: UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds. It is important to recognize these tumors as they behave differently from endometrial stromal tumors with sex cord like elements (ESTSCLE).

No MeSH data available.


Related in: MedlinePlus