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Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.

Hashmi AA, Faridi N, Edhi MM, Khan M - Int Arch Med (2014)

Bottom Line: The case was diagnosed as UTROSCT.No evidence of metastasis was found on systemic clinical and radiologic workup.UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.

ABSTRACT

Introduction: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.

Case presentation: A 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy. Gross examination revealed a gelatinous grayish white tumor confined to the myometrium, 7 cm in maximum dimention. Microscopic examination revealed monomorphic round to oval tumor cells in anastomosing cords and trabeculae with myxoid background. Immunohistochemically, tumor cells showed diffuse positivity for vimentin, CD99 and S100, while focal positivity was seen with pancytokeratin immunostain. The case was diagnosed as UTROSCT. No evidence of metastasis was found on systemic clinical and radiologic workup.

Conclusion: UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds. It is important to recognize these tumors as they behave differently from endometrial stromal tumors with sex cord like elements (ESTSCLE).

No MeSH data available.


Related in: MedlinePlus

Gross and microscopic view of UTROSCT. a: Gross view of hysterectomy specimen showing a gelatinous grayish white tumor confined to the myometrium. b: Microscopic section of the tumor showing anastomosing cords and trabeculae with myxoid background. c: Tumor interface with myometrium revealing invasive borders of the tumor. d: High power microscopic section of the tumor showing round to oval cells with vesicular nuclei and pale cytoplasm.
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Fig1: Gross and microscopic view of UTROSCT. a: Gross view of hysterectomy specimen showing a gelatinous grayish white tumor confined to the myometrium. b: Microscopic section of the tumor showing anastomosing cords and trabeculae with myxoid background. c: Tumor interface with myometrium revealing invasive borders of the tumor. d: High power microscopic section of the tumor showing round to oval cells with vesicular nuclei and pale cytoplasm.

Mentions: 48 year old post-menopausal women presented with abnormal uterine bleeding for more than 6 months unresponsive to hormonal therapy. After preoperative workup, she underwent total abdominal hysterectomy and bilateral salpingo-ophorectomy. The specimen was sent to histopathology laboratory. On gross examination, 7 × 5 × 4 cm mass was seen in myometrium. Overlying endometrium was grossly unremarkable and tumor was 2 mm was from serosal surface of the uterus. The tumor was completely confined to the myometrium. Cut surface of the tumor was gelatinous and grayish white (Figure 1a). Both ovaries were normal in size on gross examination. Microscopic sections of the tumor revealed anastomosing trabecule and cords of cells with retiform architecture at places (Figure 1b). Tumor showed focally invasive borders (Figure 1c). Background was myxoidy and areas of infarction were noted. Tumor cells showed vesicular nuclei with inconspicuous nucleoli and moderate amount of pale cytoplasm (Figure 1d). Overlying endometrium showed atrophic pattern with inactive glands and compact stroma. Both ovaries were unremarkable on histologic examination.


Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.

Hashmi AA, Faridi N, Edhi MM, Khan M - Int Arch Med (2014)

Gross and microscopic view of UTROSCT. a: Gross view of hysterectomy specimen showing a gelatinous grayish white tumor confined to the myometrium. b: Microscopic section of the tumor showing anastomosing cords and trabeculae with myxoid background. c: Tumor interface with myometrium revealing invasive borders of the tumor. d: High power microscopic section of the tumor showing round to oval cells with vesicular nuclei and pale cytoplasm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230524&req=5

Fig1: Gross and microscopic view of UTROSCT. a: Gross view of hysterectomy specimen showing a gelatinous grayish white tumor confined to the myometrium. b: Microscopic section of the tumor showing anastomosing cords and trabeculae with myxoid background. c: Tumor interface with myometrium revealing invasive borders of the tumor. d: High power microscopic section of the tumor showing round to oval cells with vesicular nuclei and pale cytoplasm.
Mentions: 48 year old post-menopausal women presented with abnormal uterine bleeding for more than 6 months unresponsive to hormonal therapy. After preoperative workup, she underwent total abdominal hysterectomy and bilateral salpingo-ophorectomy. The specimen was sent to histopathology laboratory. On gross examination, 7 × 5 × 4 cm mass was seen in myometrium. Overlying endometrium was grossly unremarkable and tumor was 2 mm was from serosal surface of the uterus. The tumor was completely confined to the myometrium. Cut surface of the tumor was gelatinous and grayish white (Figure 1a). Both ovaries were normal in size on gross examination. Microscopic sections of the tumor revealed anastomosing trabecule and cords of cells with retiform architecture at places (Figure 1b). Tumor showed focally invasive borders (Figure 1c). Background was myxoidy and areas of infarction were noted. Tumor cells showed vesicular nuclei with inconspicuous nucleoli and moderate amount of pale cytoplasm (Figure 1d). Overlying endometrium showed atrophic pattern with inactive glands and compact stroma. Both ovaries were unremarkable on histologic examination.

Bottom Line: The case was diagnosed as UTROSCT.No evidence of metastasis was found on systemic clinical and radiologic workup.UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.

ABSTRACT

Introduction: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.

Case presentation: A 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy. Gross examination revealed a gelatinous grayish white tumor confined to the myometrium, 7 cm in maximum dimention. Microscopic examination revealed monomorphic round to oval tumor cells in anastomosing cords and trabeculae with myxoid background. Immunohistochemically, tumor cells showed diffuse positivity for vimentin, CD99 and S100, while focal positivity was seen with pancytokeratin immunostain. The case was diagnosed as UTROSCT. No evidence of metastasis was found on systemic clinical and radiologic workup.

Conclusion: UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds. It is important to recognize these tumors as they behave differently from endometrial stromal tumors with sex cord like elements (ESTSCLE).

No MeSH data available.


Related in: MedlinePlus