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Using fractional polynomials to model the effect of cumulative duration of exposure on outcomes: applications to cohort and nested case-control designs.

Austin PC, Park-Wyllie LY, Juurlink DN - Pharmacoepidemiol Drug Saf (2014)

Bottom Line: Using a cohort design and a Cox proportional hazards model, we found a non-linear relationship between cumulative duration of use of the antiarrhythmic drug amiodarone and the risk of thyroid dysfunction.Using a nested case-control design and a conditional logistic regression model, we found evidence of a linear relationship between duration of use of bisphosphonate medication and risk of atypical femur fractures.Fractional polynomials allow one to model the relationship between cumulative duration of medication use and adverse outcomes.

View Article: PubMed Central - PubMed

Affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Institute of Health Management, Policy and Evaluation, University of Toronto, Toronto, Ontario, Canada; Schulich Heart Research Program, Sunnybrook Research Institute, Toronto, Canada.

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Cumulative days of medication use at the end of follow-up
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fig01: Cumulative days of medication use at the end of follow-up

Mentions: The empirical cumulative distribution function describing the distribution of cumulative duration of amiodarone exposure at the end of follow-up for each subject is described in the left panel of Figure 1.


Using fractional polynomials to model the effect of cumulative duration of exposure on outcomes: applications to cohort and nested case-control designs.

Austin PC, Park-Wyllie LY, Juurlink DN - Pharmacoepidemiol Drug Saf (2014)

Cumulative days of medication use at the end of follow-up
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230473&req=5

fig01: Cumulative days of medication use at the end of follow-up
Mentions: The empirical cumulative distribution function describing the distribution of cumulative duration of amiodarone exposure at the end of follow-up for each subject is described in the left panel of Figure 1.

Bottom Line: Using a cohort design and a Cox proportional hazards model, we found a non-linear relationship between cumulative duration of use of the antiarrhythmic drug amiodarone and the risk of thyroid dysfunction.Using a nested case-control design and a conditional logistic regression model, we found evidence of a linear relationship between duration of use of bisphosphonate medication and risk of atypical femur fractures.Fractional polynomials allow one to model the relationship between cumulative duration of medication use and adverse outcomes.

View Article: PubMed Central - PubMed

Affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Institute of Health Management, Policy and Evaluation, University of Toronto, Toronto, Ontario, Canada; Schulich Heart Research Program, Sunnybrook Research Institute, Toronto, Canada.

Show MeSH
Related in: MedlinePlus