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Quantitative biocompatibility evaluation of nickel-free high-nitrogen stainless steel in vitro/in vivo.

Inoue M, Sasaki M, Katada Y, Taguchi T - J. Biomed. Mater. Res. Part B Appl. Biomater. (2013)

Bottom Line: Endothelialization was greater with HNS than with commercial stainless steel (SUS316L).These differences may be related to the amounts of nickel ion eluted from the stents, as HNS did not elute nickel ion.These data suggest that HNS may be useful as a material for coronary artery stents.

View Article: PubMed Central - PubMed

Affiliation: Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.

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Endothelialization property of HNS and SUS316L. (a) Number of HUVECs on HNS (gray bar) and SUS316L (black bar) after cultured for 1, 3, and 7 days. Data are the average ± standard deviations (SD) of five samples, with (&) indicating p < 0.05. N.S. means no significant difference. (b) Distribution and morphology of HUVECs on HNS and SUS316L after cultured for 1, 3, and 7 days. Actin filaments (green) and cell nuclei (red) are shown.
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fig01: Endothelialization property of HNS and SUS316L. (a) Number of HUVECs on HNS (gray bar) and SUS316L (black bar) after cultured for 1, 3, and 7 days. Data are the average ± standard deviations (SD) of five samples, with (&) indicating p < 0.05. N.S. means no significant difference. (b) Distribution and morphology of HUVECs on HNS and SUS316L after cultured for 1, 3, and 7 days. Actin filaments (green) and cell nuclei (red) are shown.

Mentions: Endothelialization on the surface of coronary artery stents helps prevent in-stent thrombosis.29 Endothelialization property of the HNS and SUS316L was investigated by assessing proliferation of HUVECs. Figure 1 shows HUVEC cultures on HNS and SUS316L after 1, 3, and 7 days. There were no significant differences (p > 0.05) in the number of HUVECs at the 1-day time point when comparing HNS and SUS316L. However, the number of HUVECs at 3 days was 1.6-fold higher on HNS than on SUS316L (p < 0.05). Furthermore, the number of HUVECs on HNS was 2.8-fold higher at 3 days than at the 1-day time point. Similarly, the number of HUVECs at 7 days was 1.3-fold higher on HNS than on SUS316L, and the number of HUVECs on HNS was fourfold higher at 7 days than at the 1-day time point.


Quantitative biocompatibility evaluation of nickel-free high-nitrogen stainless steel in vitro/in vivo.

Inoue M, Sasaki M, Katada Y, Taguchi T - J. Biomed. Mater. Res. Part B Appl. Biomater. (2013)

Endothelialization property of HNS and SUS316L. (a) Number of HUVECs on HNS (gray bar) and SUS316L (black bar) after cultured for 1, 3, and 7 days. Data are the average ± standard deviations (SD) of five samples, with (&) indicating p < 0.05. N.S. means no significant difference. (b) Distribution and morphology of HUVECs on HNS and SUS316L after cultured for 1, 3, and 7 days. Actin filaments (green) and cell nuclei (red) are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230471&req=5

fig01: Endothelialization property of HNS and SUS316L. (a) Number of HUVECs on HNS (gray bar) and SUS316L (black bar) after cultured for 1, 3, and 7 days. Data are the average ± standard deviations (SD) of five samples, with (&) indicating p < 0.05. N.S. means no significant difference. (b) Distribution and morphology of HUVECs on HNS and SUS316L after cultured for 1, 3, and 7 days. Actin filaments (green) and cell nuclei (red) are shown.
Mentions: Endothelialization on the surface of coronary artery stents helps prevent in-stent thrombosis.29 Endothelialization property of the HNS and SUS316L was investigated by assessing proliferation of HUVECs. Figure 1 shows HUVEC cultures on HNS and SUS316L after 1, 3, and 7 days. There were no significant differences (p > 0.05) in the number of HUVECs at the 1-day time point when comparing HNS and SUS316L. However, the number of HUVECs at 3 days was 1.6-fold higher on HNS than on SUS316L (p < 0.05). Furthermore, the number of HUVECs on HNS was 2.8-fold higher at 3 days than at the 1-day time point. Similarly, the number of HUVECs at 7 days was 1.3-fold higher on HNS than on SUS316L, and the number of HUVECs on HNS was fourfold higher at 7 days than at the 1-day time point.

Bottom Line: Endothelialization was greater with HNS than with commercial stainless steel (SUS316L).These differences may be related to the amounts of nickel ion eluted from the stents, as HNS did not elute nickel ion.These data suggest that HNS may be useful as a material for coronary artery stents.

View Article: PubMed Central - PubMed

Affiliation: Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.

Show MeSH
Related in: MedlinePlus