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The increase in prescriptions of bisphosphonates and the incidence proportion of osteonecrosis of the jaw after risk communication activities in Japan: a hospital-based cohort study.

Sumi E, Yamazaki T, Tanaka S, Yamamoto K, Nakayama T, Bessho K, Yokode M - Pharmacoepidemiol Drug Saf (2014)

Bottom Line: Twenty times more cases of ONJ have been reported to regulatory authority since 2007, compared with the period before 2007.In our cohort, the incidence proportion of ONJ during and after 2009 was four times greater than before 2009.However, there was no surveillance for ONJ before the revision.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University, Kyoto, Japan.

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Related in: MedlinePlus

The number of patients prescribed each agent for osteoporosis in the cohort. Legend: The numbers of patients prescribed bisphosphonates, estrogen and a selective estrogen receptor modulator, as well as other agents for osteoporosis, each year in a cohort of 6293 osteoporosis patients are illustrated with a dark gray line of diamonds, a gray line of triangles and a light gray line of squares, respectively. The year 2000 contains 2 months, and the year 2010 contains 10 months. The numbers of patients receiving osteoporosis medications in each year are shown below the graph
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fig02: The number of patients prescribed each agent for osteoporosis in the cohort. Legend: The numbers of patients prescribed bisphosphonates, estrogen and a selective estrogen receptor modulator, as well as other agents for osteoporosis, each year in a cohort of 6293 osteoporosis patients are illustrated with a dark gray line of diamonds, a gray line of triangles and a light gray line of squares, respectively. The year 2000 contains 2 months, and the year 2010 contains 10 months. The numbers of patients receiving osteoporosis medications in each year are shown below the graph

Mentions: The number of BP users has been increasing steadily since 2000 (Figure 2). The number of estrogen users, including users of selective estrogen receptor modulators, has been low. The number of users of other osteoporosis medications, including active vitamin D3 or calcium, increased before 2006 and since then has remained approximately constant.


The increase in prescriptions of bisphosphonates and the incidence proportion of osteonecrosis of the jaw after risk communication activities in Japan: a hospital-based cohort study.

Sumi E, Yamazaki T, Tanaka S, Yamamoto K, Nakayama T, Bessho K, Yokode M - Pharmacoepidemiol Drug Saf (2014)

The number of patients prescribed each agent for osteoporosis in the cohort. Legend: The numbers of patients prescribed bisphosphonates, estrogen and a selective estrogen receptor modulator, as well as other agents for osteoporosis, each year in a cohort of 6293 osteoporosis patients are illustrated with a dark gray line of diamonds, a gray line of triangles and a light gray line of squares, respectively. The year 2000 contains 2 months, and the year 2010 contains 10 months. The numbers of patients receiving osteoporosis medications in each year are shown below the graph
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230466&req=5

fig02: The number of patients prescribed each agent for osteoporosis in the cohort. Legend: The numbers of patients prescribed bisphosphonates, estrogen and a selective estrogen receptor modulator, as well as other agents for osteoporosis, each year in a cohort of 6293 osteoporosis patients are illustrated with a dark gray line of diamonds, a gray line of triangles and a light gray line of squares, respectively. The year 2000 contains 2 months, and the year 2010 contains 10 months. The numbers of patients receiving osteoporosis medications in each year are shown below the graph
Mentions: The number of BP users has been increasing steadily since 2000 (Figure 2). The number of estrogen users, including users of selective estrogen receptor modulators, has been low. The number of users of other osteoporosis medications, including active vitamin D3 or calcium, increased before 2006 and since then has remained approximately constant.

Bottom Line: Twenty times more cases of ONJ have been reported to regulatory authority since 2007, compared with the period before 2007.In our cohort, the incidence proportion of ONJ during and after 2009 was four times greater than before 2009.However, there was no surveillance for ONJ before the revision.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University, Kyoto, Japan.

Show MeSH
Related in: MedlinePlus