The increase in prescriptions of bisphosphonates and the incidence proportion of osteonecrosis of the jaw after risk communication activities in Japan: a hospital-based cohort study.
Bottom Line: Twenty times more cases of ONJ have been reported to regulatory authority since 2007, compared with the period before 2007.In our cohort, the incidence proportion of ONJ during and after 2009 was four times greater than before 2009.However, there was no surveillance for ONJ before the revision.
Affiliation: Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University, Kyoto, Japan.Show MeSH
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Mentions: The number of BP users has been increasing steadily since 2000 (Figure 2). The number of estrogen users, including users of selective estrogen receptor modulators, has been low. The number of users of other osteoporosis medications, including active vitamin D3 or calcium, increased before 2006 and since then has remained approximately constant.
Affiliation: Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University, Kyoto, Japan.