Limits...
Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders.

Jen A, Saunders EF, Ornstein RM, Kamali M, McInnis MG - Int J Bipolar Disord (2013)

Bottom Line: Childhood trauma was associated with ED.Impulsivity and anxiety associated with BD may fuel ED and put patients at risk for other impulsivity-related disorders such as alcohol use disorders.ED was associated with more severe and variable moods and more frequent depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, 500 University Drive, P.O. Box 850, Mail Code HO73, Hershey, PA 17033-0850 USA.

ABSTRACT

Background: Eating disorders (ED) are noted to occur with bipolar disorder (BD), but relationships between additional comorbidities, clinical correlates, and personality factors common to both remain largely unknown.

Methods: Using data from the Prechter Longitudinal Study of Bipolar Disorder, we measured the prevalence and demographic factors of comorbid ED with BD, presence of additional comorbidity of anxiety and substance use disorders, psychosis, suicide attempts, mixed symptoms, childhood abuse, impact of NEO-Personality Inventory (NEO-PI) personality factors, and mood outcome in 354 patients with BD. We analyzed the prevalence of ED using both broad and narrow criteria.

Results and discussion: ED was more common in the Prechter BD sample than the general population, with the majority of those with ED being female. Anxiety disorders, alcohol abuse/dependence, and NEO-PI N5 impulsiveness were independently associated with ED in a multivariable linear regression analysis. BD age at onset was earlier in the ED group than that in the non-ED group and was earlier than the average onset of ED. Anxiety occurred before ED and alcohol use disorders after both BD and ED. Childhood trauma was associated with ED. Impulsivity and anxiety associated with BD may fuel ED and put patients at risk for other impulsivity-related disorders such as alcohol use disorders. ED was associated with more severe and variable moods and more frequent depression. Patients with BD should be regularly screened for ED, anxiety disorders, and alcohol use disorders, and comorbidity should be promptly addressed.

No MeSH data available.


Related in: MedlinePlus

Age at onset of BD, EDs, anxiety disorders, and alcohol use disorder. Asterisk indicates that differences between those with and without ED are statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4230429&req=5

Fig1: Age at onset of BD, EDs, anxiety disorders, and alcohol use disorder. Asterisk indicates that differences between those with and without ED are statistically significant.

Mentions: The onset of ED occurred on average at 19 ± 9 years of age for the entire ED group, but the onset of AN was the youngest at 17 ± 6 years, followed by BN at 20 ± 7 years and BED at 21 ± 11 years. Age at onset of anxiety disorders was significantly lower in the ED group than in the non-ED group, but the age at onset of alcohol use disorders did not differ (Figure 1, Table 3). Anxiety in the ED group most commonly preceded the onset of ED, but alcohol abuse/dependence followed the onset of ED (Figure 1, Table 3). Of the specific anxiety disorders, only panic disorder had a significantly lower age at onset in the ED group (onset at 16 ± 11 years compared to 23 ± 10 years in the non-ED group). However, social phobia had an average onset at 13 ± 7 years compared to 18 ± 11 years and specific phobia at 14 ± 9 years compared to 15 ± 13 years. These differences may be significant with a larger sample size. The onset of OCD was similar in both groups (19 ± 14 years vs 20 ± 10 years).Figure 1


Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders.

Jen A, Saunders EF, Ornstein RM, Kamali M, McInnis MG - Int J Bipolar Disord (2013)

Age at onset of BD, EDs, anxiety disorders, and alcohol use disorder. Asterisk indicates that differences between those with and without ED are statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230429&req=5

Fig1: Age at onset of BD, EDs, anxiety disorders, and alcohol use disorder. Asterisk indicates that differences between those with and without ED are statistically significant.
Mentions: The onset of ED occurred on average at 19 ± 9 years of age for the entire ED group, but the onset of AN was the youngest at 17 ± 6 years, followed by BN at 20 ± 7 years and BED at 21 ± 11 years. Age at onset of anxiety disorders was significantly lower in the ED group than in the non-ED group, but the age at onset of alcohol use disorders did not differ (Figure 1, Table 3). Anxiety in the ED group most commonly preceded the onset of ED, but alcohol abuse/dependence followed the onset of ED (Figure 1, Table 3). Of the specific anxiety disorders, only panic disorder had a significantly lower age at onset in the ED group (onset at 16 ± 11 years compared to 23 ± 10 years in the non-ED group). However, social phobia had an average onset at 13 ± 7 years compared to 18 ± 11 years and specific phobia at 14 ± 9 years compared to 15 ± 13 years. These differences may be significant with a larger sample size. The onset of OCD was similar in both groups (19 ± 14 years vs 20 ± 10 years).Figure 1

Bottom Line: Childhood trauma was associated with ED.Impulsivity and anxiety associated with BD may fuel ED and put patients at risk for other impulsivity-related disorders such as alcohol use disorders.ED was associated with more severe and variable moods and more frequent depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, 500 University Drive, P.O. Box 850, Mail Code HO73, Hershey, PA 17033-0850 USA.

ABSTRACT

Background: Eating disorders (ED) are noted to occur with bipolar disorder (BD), but relationships between additional comorbidities, clinical correlates, and personality factors common to both remain largely unknown.

Methods: Using data from the Prechter Longitudinal Study of Bipolar Disorder, we measured the prevalence and demographic factors of comorbid ED with BD, presence of additional comorbidity of anxiety and substance use disorders, psychosis, suicide attempts, mixed symptoms, childhood abuse, impact of NEO-Personality Inventory (NEO-PI) personality factors, and mood outcome in 354 patients with BD. We analyzed the prevalence of ED using both broad and narrow criteria.

Results and discussion: ED was more common in the Prechter BD sample than the general population, with the majority of those with ED being female. Anxiety disorders, alcohol abuse/dependence, and NEO-PI N5 impulsiveness were independently associated with ED in a multivariable linear regression analysis. BD age at onset was earlier in the ED group than that in the non-ED group and was earlier than the average onset of ED. Anxiety occurred before ED and alcohol use disorders after both BD and ED. Childhood trauma was associated with ED. Impulsivity and anxiety associated with BD may fuel ED and put patients at risk for other impulsivity-related disorders such as alcohol use disorders. ED was associated with more severe and variable moods and more frequent depression. Patients with BD should be regularly screened for ED, anxiety disorders, and alcohol use disorders, and comorbidity should be promptly addressed.

No MeSH data available.


Related in: MedlinePlus