The association of maternal prenatal psychosocial stress with vascular function in the child at age 10-11 years: findings from the Avon longitudinal study of parents and children.
Bottom Line: Paternal symptoms were not associated with offspring outcomes.Maternal postnatal depressive symptoms were associated with lower offspring SBP.We found no evidence to support the hypothesis that maternal stress during pregnancy adversely affects offspring vascular function at age 10-12 years via intrauterine mechanisms.
Affiliation: University of Amsterdam, Amsterdam, The Netherlands Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands firstname.lastname@example.org.Show MeSH
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Mentions: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective population-based birth cohort that recruited 14,541 pregnant women resident in Avon, UK with expected dates of delivery 1 April 1991 to 31 December 1992 were used. Additional details of the study can be found on the study website (www.alspac.bris.ac.uk) and in previous publications.24–26Figure 1 shows the flow of participants through the study. In this study, we included mother–offspring pairs where there was a singleton pregnancy resulting in a live birth with the child surviving to at least 1 year of age. The eligible cohort for the current analyses was the 4318 mother–offspring pairs who had complete data on maternal depressive symptoms and anxiety at both gestational time points, offspring blood pressure (obtained at the 10–11-year follow-up clinic), and complete data on all covariates.Figure 1.
Affiliation: University of Amsterdam, Amsterdam, The Netherlands Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands email@example.com.