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Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels.

Åkerfeldt T, Gunningberg L, Swenne CL, Ronquist G, Larsson A - Eur. J. Med. Res. (2014)

Bottom Line: Serum endostatin levels were measured by ELISA.Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.Serum endostatin is reduced 30 days after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. torbjorn.akerfeldt@akademiska.se.

ABSTRACT

Background: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.

Methods: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.

Results: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.

Conclusion: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.

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Related in: MedlinePlus

Endostatin and C-reactive protein (CRP) values in individual patients at day 0, day 4 and day 30 after orthopedic surgery.
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Fig1: Endostatin and C-reactive protein (CRP) values in individual patients at day 0, day 4 and day 30 after orthopedic surgery.

Mentions: The mean age was 67 years (range 45 to 80 years) for the orthopedic patients and 69 years (range 48 to 84 years) for the cardiopulmonary bypass patients. In the orthopedic group (Figure 1), median CRP value prior to surgery was 1.9 mg/L (IQR 1.2 – 8.7). Four days after surgery the median value was 137.3 mg/L (IQR 104.1 – 178.2) and 30 days after surgery the median value was 5.1 mg/L (IQR 2.1 – 11.2). The corresponding values for the cardiopulmonary surgery group (Figure 2) was: CRP value prior to surgery 3.3 mg/L (IQR 1.0 – 7.6), 4 days after surgery 167.0 mg/L (103.7 – 222.7) and 30 days after surgery 3.4 mg/L (2.0 – 5.6).Figure 1


Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels.

Åkerfeldt T, Gunningberg L, Swenne CL, Ronquist G, Larsson A - Eur. J. Med. Res. (2014)

Endostatin and C-reactive protein (CRP) values in individual patients at day 0, day 4 and day 30 after orthopedic surgery.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4230358&req=5

Fig1: Endostatin and C-reactive protein (CRP) values in individual patients at day 0, day 4 and day 30 after orthopedic surgery.
Mentions: The mean age was 67 years (range 45 to 80 years) for the orthopedic patients and 69 years (range 48 to 84 years) for the cardiopulmonary bypass patients. In the orthopedic group (Figure 1), median CRP value prior to surgery was 1.9 mg/L (IQR 1.2 – 8.7). Four days after surgery the median value was 137.3 mg/L (IQR 104.1 – 178.2) and 30 days after surgery the median value was 5.1 mg/L (IQR 2.1 – 11.2). The corresponding values for the cardiopulmonary surgery group (Figure 2) was: CRP value prior to surgery 3.3 mg/L (IQR 1.0 – 7.6), 4 days after surgery 167.0 mg/L (103.7 – 222.7) and 30 days after surgery 3.4 mg/L (2.0 – 5.6).Figure 1

Bottom Line: Serum endostatin levels were measured by ELISA.Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.Serum endostatin is reduced 30 days after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. torbjorn.akerfeldt@akademiska.se.

ABSTRACT

Background: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.

Methods: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.

Results: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.

Conclusion: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.

Show MeSH
Related in: MedlinePlus