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Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas.

Watanabe S, Sawada M, Ishizaki S, Kobayashi K, Tanaka M - Dermatol Pract Concept (2014)

Bottom Line: All the cases with nevi showed regular FP showing regular distribution of fibrils, whereas all the melanomas showed irregular distribution of fibrils and colors.White fibrils corresponding to the eccrine ducts in the horny layer were more often present on the ridges in ALM, which showed negative FP.Differentiating between the regular and irregular FP, including negative FP, might be helpful for the discrimination of melanoma from nevus.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tokyo Woman's Medical University Medical Center East, Tokyo, Japan.

ABSTRACT

Background: Because body weight-bearing produces a shift in the horny layer, acral melanocytic nevus on the body weight-bearing area of the sole showed a regular fibrillar pattern (FP) due to slanting of the melanin columns in the horny layer. On the other hand, acral lentiginous melanoma (ALM) on the body weight-bearing area of the sole tended to show irregular fibrillar pattern showing rather structureless pigmentation instead of a parallel ridge pattern, which is due to the shift of the horny layer.

Objective: To elucidate the subtle difference between the regular FP of nevus and irregular FP in ALM.

Methods: In this study, the dermatoscopic features of five cases of ALM and five cases of acral melanocytic nevus on the weight-bearing area of the sole were compared.

Results: All the cases with nevi showed regular FP showing regular distribution of fibrils, whereas all the melanomas showed irregular distribution of fibrils and colors. Fibrils in nevi tended to be clear at the furrows and dim at the ridges. White fibrils corresponding to the eccrine ducts in the horny layer were more often present on the ridges in ALM, which showed negative FP.

Conclusion: Differentiating between the regular and irregular FP, including negative FP, might be helpful for the discrimination of melanoma from nevus.

No MeSH data available.


Related in: MedlinePlus

Dermatoscopy of acral lentiginous melanoma located ALM on the left sole near the fifth toe. The non-loaded area showed the typical parallel ridge pattern and regular white dots corresponding to the eccrine pores on the center of the ridges. The loaded area showed a more homogeneous brown pigmentation and a short negative fibrillar pattern was observed. (Copyright: ©2014 Watanabe et al.)
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f1-dp0404a08: Dermatoscopy of acral lentiginous melanoma located ALM on the left sole near the fifth toe. The non-loaded area showed the typical parallel ridge pattern and regular white dots corresponding to the eccrine pores on the center of the ridges. The loaded area showed a more homogeneous brown pigmentation and a short negative fibrillar pattern was observed. (Copyright: ©2014 Watanabe et al.)

Mentions: However, on the weight-bearing area of the feet, ALM often shows structureless pigmentation instead of PRP and 10% of acral melanocytic nevi show an atypical pattern [5,7]. ALM sometimes shows whitish fibrils corresponding to eccrine ducts in the horny layer of the ridge of the structureless pigmentation, which we term “negative FP” (Figure 1). Negative FP is composed of whitish fibrils, corresponding to the elongated eccrine ducts, and the diffuse pigmentation as a background. This is often observed in ALM on the weight-bearing area, although it is seldom found in acral nevus in the same area. The reason for negative FP is probably due to the much darker background in ALM than that in nevus.


Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas.

Watanabe S, Sawada M, Ishizaki S, Kobayashi K, Tanaka M - Dermatol Pract Concept (2014)

Dermatoscopy of acral lentiginous melanoma located ALM on the left sole near the fifth toe. The non-loaded area showed the typical parallel ridge pattern and regular white dots corresponding to the eccrine pores on the center of the ridges. The loaded area showed a more homogeneous brown pigmentation and a short negative fibrillar pattern was observed. (Copyright: ©2014 Watanabe et al.)
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4230258&req=5

f1-dp0404a08: Dermatoscopy of acral lentiginous melanoma located ALM on the left sole near the fifth toe. The non-loaded area showed the typical parallel ridge pattern and regular white dots corresponding to the eccrine pores on the center of the ridges. The loaded area showed a more homogeneous brown pigmentation and a short negative fibrillar pattern was observed. (Copyright: ©2014 Watanabe et al.)
Mentions: However, on the weight-bearing area of the feet, ALM often shows structureless pigmentation instead of PRP and 10% of acral melanocytic nevi show an atypical pattern [5,7]. ALM sometimes shows whitish fibrils corresponding to eccrine ducts in the horny layer of the ridge of the structureless pigmentation, which we term “negative FP” (Figure 1). Negative FP is composed of whitish fibrils, corresponding to the elongated eccrine ducts, and the diffuse pigmentation as a background. This is often observed in ALM on the weight-bearing area, although it is seldom found in acral nevus in the same area. The reason for negative FP is probably due to the much darker background in ALM than that in nevus.

Bottom Line: All the cases with nevi showed regular FP showing regular distribution of fibrils, whereas all the melanomas showed irregular distribution of fibrils and colors.White fibrils corresponding to the eccrine ducts in the horny layer were more often present on the ridges in ALM, which showed negative FP.Differentiating between the regular and irregular FP, including negative FP, might be helpful for the discrimination of melanoma from nevus.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tokyo Woman's Medical University Medical Center East, Tokyo, Japan.

ABSTRACT

Background: Because body weight-bearing produces a shift in the horny layer, acral melanocytic nevus on the body weight-bearing area of the sole showed a regular fibrillar pattern (FP) due to slanting of the melanin columns in the horny layer. On the other hand, acral lentiginous melanoma (ALM) on the body weight-bearing area of the sole tended to show irregular fibrillar pattern showing rather structureless pigmentation instead of a parallel ridge pattern, which is due to the shift of the horny layer.

Objective: To elucidate the subtle difference between the regular FP of nevus and irregular FP in ALM.

Methods: In this study, the dermatoscopic features of five cases of ALM and five cases of acral melanocytic nevus on the weight-bearing area of the sole were compared.

Results: All the cases with nevi showed regular FP showing regular distribution of fibrils, whereas all the melanomas showed irregular distribution of fibrils and colors. Fibrils in nevi tended to be clear at the furrows and dim at the ridges. White fibrils corresponding to the eccrine ducts in the horny layer were more often present on the ridges in ALM, which showed negative FP.

Conclusion: Differentiating between the regular and irregular FP, including negative FP, might be helpful for the discrimination of melanoma from nevus.

No MeSH data available.


Related in: MedlinePlus