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A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus

Correlations between the differences in the axial length, refractive error, and BCVA versus the differences in the SD-OCT parameters between the amblyopic and fellow eyes.Notes: The difference value shows deducted measurements of amblyopic eyes from those of fellow eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.Abbreviations: BCVA, best corrected visual acuity; cpRNFL, circumpapillary retinal nerve fiber layer; logMAR, logarithm of the minimal angle of resolution; SD-OCT, spectral domain optical coherence tomography.
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f3-opth-8-2199: Correlations between the differences in the axial length, refractive error, and BCVA versus the differences in the SD-OCT parameters between the amblyopic and fellow eyes.Notes: The difference value shows deducted measurements of amblyopic eyes from those of fellow eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.Abbreviations: BCVA, best corrected visual acuity; cpRNFL, circumpapillary retinal nerve fiber layer; logMAR, logarithm of the minimal angle of resolution; SD-OCT, spectral domain optical coherence tomography.

Mentions: Figure 3 shows the correlations between the differences in axial length, refractive error, and BCVA versus the differences in the cpRNFL, macular retinal thicknesses, and rim area. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.


A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Correlations between the differences in the axial length, refractive error, and BCVA versus the differences in the SD-OCT parameters between the amblyopic and fellow eyes.Notes: The difference value shows deducted measurements of amblyopic eyes from those of fellow eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.Abbreviations: BCVA, best corrected visual acuity; cpRNFL, circumpapillary retinal nerve fiber layer; logMAR, logarithm of the minimal angle of resolution; SD-OCT, spectral domain optical coherence tomography.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4230232&req=5

f3-opth-8-2199: Correlations between the differences in the axial length, refractive error, and BCVA versus the differences in the SD-OCT parameters between the amblyopic and fellow eyes.Notes: The difference value shows deducted measurements of amblyopic eyes from those of fellow eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.Abbreviations: BCVA, best corrected visual acuity; cpRNFL, circumpapillary retinal nerve fiber layer; logMAR, logarithm of the minimal angle of resolution; SD-OCT, spectral domain optical coherence tomography.
Mentions: Figure 3 shows the correlations between the differences in axial length, refractive error, and BCVA versus the differences in the cpRNFL, macular retinal thicknesses, and rim area. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or BCVA.

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus