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A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus

Measurement of the GCC and ONH in a normal subject using RTVue-100®.Notes: (A) GCC protocol. (B) ONH protocol. The ONH measurements are performed within the area marked with the line.Abbreviations: GCC, ganglion cell complex; ONH, optic nerve head; T, temporal; N, nasal; SN, superior nasal; NU, nasal upper; NL, nasal lower; IN, inferior nasal; IT, inferior temporal; TL, temporal lower; TU, temporal upper; ST, superior temporal.
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f2-opth-8-2199: Measurement of the GCC and ONH in a normal subject using RTVue-100®.Notes: (A) GCC protocol. (B) ONH protocol. The ONH measurements are performed within the area marked with the line.Abbreviations: GCC, ganglion cell complex; ONH, optic nerve head; T, temporal; N, nasal; SN, superior nasal; NU, nasal upper; NL, nasal lower; IN, inferior nasal; IT, inferior temporal; TL, temporal lower; TU, temporal upper; ST, superior temporal.

Mentions: The GCC protocol was used to obtain the macular measurements. This protocol consists of one horizontal line scan measuring 7 mm in length (467 A-scans) and 15 vertical line scans measuring 7 mm in length (each 400 A-scans) obtained at 0.5 mm intervals (Figure 2A). The GCC is measured from the ILM to the outer boundary of the inner plexiform layer (IPL), similar to the macular inner retinal thickness in MM5. The center of the GCC scan is shifted 0.75 mm temporally to improve sampling of the temporal periphery as part of the glaucoma-analysis program. This scan configuration provides 14,810 A-scans in 0.58 seconds.


A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Measurement of the GCC and ONH in a normal subject using RTVue-100®.Notes: (A) GCC protocol. (B) ONH protocol. The ONH measurements are performed within the area marked with the line.Abbreviations: GCC, ganglion cell complex; ONH, optic nerve head; T, temporal; N, nasal; SN, superior nasal; NU, nasal upper; NL, nasal lower; IN, inferior nasal; IT, inferior temporal; TL, temporal lower; TU, temporal upper; ST, superior temporal.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230232&req=5

f2-opth-8-2199: Measurement of the GCC and ONH in a normal subject using RTVue-100®.Notes: (A) GCC protocol. (B) ONH protocol. The ONH measurements are performed within the area marked with the line.Abbreviations: GCC, ganglion cell complex; ONH, optic nerve head; T, temporal; N, nasal; SN, superior nasal; NU, nasal upper; NL, nasal lower; IN, inferior nasal; IT, inferior temporal; TL, temporal lower; TU, temporal upper; ST, superior temporal.
Mentions: The GCC protocol was used to obtain the macular measurements. This protocol consists of one horizontal line scan measuring 7 mm in length (467 A-scans) and 15 vertical line scans measuring 7 mm in length (each 400 A-scans) obtained at 0.5 mm intervals (Figure 2A). The GCC is measured from the ILM to the outer boundary of the inner plexiform layer (IPL), similar to the macular inner retinal thickness in MM5. The center of the GCC scan is shifted 0.75 mm temporally to improve sampling of the temporal periphery as part of the glaucoma-analysis program. This scan configuration provides 14,810 A-scans in 0.58 seconds.

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus