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A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus

Measurement of the MM5 in a normal subject using RTVue-100®.Notes: (A) MM5 protocol. (B) ILM-IPL: from the ILM to the outer boundary of the IPL. INL-RPE: from the inner border of the INL to the outer border of the RPE. ILM-RPE: from the ILM to the outer border of the RPE. (C) “1 mm” is a region of within 1 mm of the diameter from the center. “3 mm” is a region of between 1 and 3 mm of the diameter from the center.Abbreviations: ILM, inner limiting membrane; IPL, inner plexiform layer; INL, inner nuclear layer; RPE, retinal pigment epithelium; S, superior; N, nasal; I, inferior; T, temporal.
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f1-opth-8-2199: Measurement of the MM5 in a normal subject using RTVue-100®.Notes: (A) MM5 protocol. (B) ILM-IPL: from the ILM to the outer boundary of the IPL. INL-RPE: from the inner border of the INL to the outer border of the RPE. ILM-RPE: from the ILM to the outer border of the RPE. (C) “1 mm” is a region of within 1 mm of the diameter from the center. “3 mm” is a region of between 1 and 3 mm of the diameter from the center.Abbreviations: ILM, inner limiting membrane; IPL, inner plexiform layer; INL, inner nuclear layer; RPE, retinal pigment epithelium; S, superior; N, nasal; I, inferior; T, temporal.

Mentions: The macular thickness was determined using the MM5 protocol in which data are acquired along a 5×5 mm2 grid of eleven horizontal and eleven vertical lines (each 668 A- scans) at 0.5 mm intervals and an inner 3×3 mm2 grid of six horizontal and six vertical lines (each 400 A-scans) at 0.5 mm intervals (Figure 1A). The built-in software program allows for the automated segmentation of the macular full retinal thickness (from the inner limiting membrane [ILM] to the outer border of the retinal pigment epithelium [RPE]) as well as the macular inner retinal thickness (from the ILM to the outer boundary of the inner plexiform layer) and macular outer retinal thickness (from the inner border of the inner nuclear layer to the outer border of the RPE) (Figure 1B). The retinal macular thickness was measured in two regions, which included regions within 1 mm (“1 mm” region) and between 1 and 3 mm (“3 mm” region) from the center (Figure 1C).


A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography.

Araki S, Miki A, Yamashita T, Goto K, Haruishi K, Ieki Y, Kiryu J - Clin Ophthalmol (2014)

Measurement of the MM5 in a normal subject using RTVue-100®.Notes: (A) MM5 protocol. (B) ILM-IPL: from the ILM to the outer boundary of the IPL. INL-RPE: from the inner border of the INL to the outer border of the RPE. ILM-RPE: from the ILM to the outer border of the RPE. (C) “1 mm” is a region of within 1 mm of the diameter from the center. “3 mm” is a region of between 1 and 3 mm of the diameter from the center.Abbreviations: ILM, inner limiting membrane; IPL, inner plexiform layer; INL, inner nuclear layer; RPE, retinal pigment epithelium; S, superior; N, nasal; I, inferior; T, temporal.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230232&req=5

f1-opth-8-2199: Measurement of the MM5 in a normal subject using RTVue-100®.Notes: (A) MM5 protocol. (B) ILM-IPL: from the ILM to the outer boundary of the IPL. INL-RPE: from the inner border of the INL to the outer border of the RPE. ILM-RPE: from the ILM to the outer border of the RPE. (C) “1 mm” is a region of within 1 mm of the diameter from the center. “3 mm” is a region of between 1 and 3 mm of the diameter from the center.Abbreviations: ILM, inner limiting membrane; IPL, inner plexiform layer; INL, inner nuclear layer; RPE, retinal pigment epithelium; S, superior; N, nasal; I, inferior; T, temporal.
Mentions: The macular thickness was determined using the MM5 protocol in which data are acquired along a 5×5 mm2 grid of eleven horizontal and eleven vertical lines (each 668 A- scans) at 0.5 mm intervals and an inner 3×3 mm2 grid of six horizontal and six vertical lines (each 400 A-scans) at 0.5 mm intervals (Figure 1A). The built-in software program allows for the automated segmentation of the macular full retinal thickness (from the inner limiting membrane [ILM] to the outer border of the retinal pigment epithelium [RPE]) as well as the macular inner retinal thickness (from the ILM to the outer boundary of the inner plexiform layer) and macular outer retinal thickness (from the inner border of the inner nuclear layer to the outer border of the RPE) (Figure 1B). The retinal macular thickness was measured in two regions, which included regions within 1 mm (“1 mm” region) and between 1 and 3 mm (“3 mm” region) from the center (Figure 1C).

Bottom Line: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001).The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan.

ABSTRACT

Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.

Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).

Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=-0.48; P<0.01, r=-0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.

Conclusion: We found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

No MeSH data available.


Related in: MedlinePlus