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Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

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Related in: MedlinePlus

Funnel plots for the clinical significance of resistin expression in osteoarthritis patients. Each point represents a separate study for the indicated association. Horizontal line, mean magnitude of the effect.
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fig6: Funnel plots for the clinical significance of resistin expression in osteoarthritis patients. Each point represents a separate study for the indicated association. Horizontal line, mean magnitude of the effect.

Mentions: We conducted further sensitivity analyses to determine whether review conclusions were affected by the inclusion of a single study. Our findings suggested that no single study had an effect on the pooled SMDs in the current meta-analysis (Figure 5). Finally, Egger's regression test showed no evidence of asymmetrical distribution in the funnel plot in the association of resistin levels and the pathogenesis of OA (male versus female: t = 1.46, P = 0.382; cases versus controls: t = 1.20, P = 0.295) (Figure 6).


Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Funnel plots for the clinical significance of resistin expression in osteoarthritis patients. Each point represents a separate study for the indicated association. Horizontal line, mean magnitude of the effect.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230214&req=5

fig6: Funnel plots for the clinical significance of resistin expression in osteoarthritis patients. Each point represents a separate study for the indicated association. Horizontal line, mean magnitude of the effect.
Mentions: We conducted further sensitivity analyses to determine whether review conclusions were affected by the inclusion of a single study. Our findings suggested that no single study had an effect on the pooled SMDs in the current meta-analysis (Figure 5). Finally, Egger's regression test showed no evidence of asymmetrical distribution in the funnel plot in the association of resistin levels and the pathogenesis of OA (male versus female: t = 1.46, P = 0.382; cases versus controls: t = 1.20, P = 0.295) (Figure 6).

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

Show MeSH
Related in: MedlinePlus