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Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

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Subgroup analyses for the clinical significance of resistin expression in osteoarthritis patients.
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fig4: Subgroup analyses for the clinical significance of resistin expression in osteoarthritis patients.

Mentions: In the country-stratified subgroups, the results only yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup (SMD = 2.95, 95% CI = 1.97~3.93, P < 0.001), but a similar correlation was not observed in the French subgroup and the USA subgroup (all P > 0.05). Based on the resistin levels in OA cases and controls, we found that resistin levels were heightened in OA patients in comparison with the controls in the Dutch population (SMD = 0.32, 95% CI = 0.10~0.54, P = 0.004) and the Korean population (SMD = 2.20, 95% CI = 1.80~2.59, P < 0.001). This difference did not manifest in the Czech population (P > 0.05) (Figure 4).


Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Subgroup analyses for the clinical significance of resistin expression in osteoarthritis patients.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230214&req=5

fig4: Subgroup analyses for the clinical significance of resistin expression in osteoarthritis patients.
Mentions: In the country-stratified subgroups, the results only yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup (SMD = 2.95, 95% CI = 1.97~3.93, P < 0.001), but a similar correlation was not observed in the French subgroup and the USA subgroup (all P > 0.05). Based on the resistin levels in OA cases and controls, we found that resistin levels were heightened in OA patients in comparison with the controls in the Dutch population (SMD = 0.32, 95% CI = 0.10~0.54, P = 0.004) and the Korean population (SMD = 2.20, 95% CI = 1.80~2.59, P < 0.001). This difference did not manifest in the Czech population (P > 0.05) (Figure 4).

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

Show MeSH
Related in: MedlinePlus