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Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

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Related in: MedlinePlus

Flow chart showing study selection procedure. Seven clinical studies were included in this meta-analysis.
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fig1: Flow chart showing study selection procedure. Seven clinical studies were included in this meta-analysis.

Mentions: The combined electronic and manual search initially resulted in 32 potentially eligible articles. One duplicate study was removed, and then the retrieved studies were screened by title and abstract for relevance. 16 irrelevant articles were excluded. Then we systematically reviewed the remaining 15 articles with a full-text reading. Subsequently, 6 articles were deemed unsuitable and were therefore excluded; thus 9 articles were identified to be included in qualitative analysis. In addition, another 2 studies were excluded due to lack of data integrity after a more careful assessment of the remaining articles. Finally, 7 case-control studies consisting of 375 OA patients and 214 controls, including 3 sex-stratified analyses composed of 53 males and 104 females, were incorporated into the current meta-analysis with sample sizes ranging from 34 to 304 subjects [12, 21–24, 32, 33]. A flow diagram of the study selection's progression and the main reasons for exclusion is displayed in Figure 1. All eligible studies were published from 2008 to 2014 (Figure 2). Most enrolled papers showed moderate to high quality.


Clinical significance of resistin expression in osteoarthritis: a meta-analysis.

Li XC, Tian F, Wang F - Biomed Res Int (2014)

Flow chart showing study selection procedure. Seven clinical studies were included in this meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230214&req=5

fig1: Flow chart showing study selection procedure. Seven clinical studies were included in this meta-analysis.
Mentions: The combined electronic and manual search initially resulted in 32 potentially eligible articles. One duplicate study was removed, and then the retrieved studies were screened by title and abstract for relevance. 16 irrelevant articles were excluded. Then we systematically reviewed the remaining 15 articles with a full-text reading. Subsequently, 6 articles were deemed unsuitable and were therefore excluded; thus 9 articles were identified to be included in qualitative analysis. In addition, another 2 studies were excluded due to lack of data integrity after a more careful assessment of the remaining articles. Finally, 7 case-control studies consisting of 375 OA patients and 214 controls, including 3 sex-stratified analyses composed of 53 males and 104 females, were incorporated into the current meta-analysis with sample sizes ranging from 34 to 304 subjects [12, 21–24, 32, 33]. A flow diagram of the study selection's progression and the main reasons for exclusion is displayed in Figure 1. All eligible studies were published from 2008 to 2014 (Figure 2). Most enrolled papers showed moderate to high quality.

Bottom Line: Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis.Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall.

View Article: PubMed Central - PubMed

Affiliation: Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping Distrct, Shenyang 110001, China.

ABSTRACT

Background: The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.

Method: Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.

Results: Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.

Conclusion: These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

Show MeSH
Related in: MedlinePlus