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Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease.

Brill SE, Wedzicha JA - Int J Chron Obstruct Pulmon Dis (2014)

Bottom Line: Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support.The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suffered by many patients during this high-risk period.We also review current recommendations for best practice, including methods for improving oxygen provision in the future.

View Article: PubMed Central - PubMed

Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK.

ABSTRACT
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the history of this debilitating lung condition. Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support. The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suffered by many patients during this high-risk period. This review article examines the evidence underlying supplemental oxygen therapy during exacerbations of COPD. We first discuss the epidemiology and pathophysiology of respiratory failure in COPD during exacerbations. The rationale and evidence underlying oxygen therapy, including the risks when administered inappropriately, are then discussed, along with further strategies for ventilatory support. We also review current recommendations for best practice, including methods for improving oxygen provision in the future.

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General principles of titrated oxygen therapy.
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f2-copd-9-1241: General principles of titrated oxygen therapy.

Mentions: The key to achieving appropriate levels of oxygenation is using controlled oxygen therapy, with the patient’s oxygen level monitored and the supplemental oxygen therapy titrated to achieve acceptable saturations. This approach is summarized in Figure 2. Titration can be achieved either by altering the oxygen flow rate or, with certain delivery devices, administering a mixture of air and oxygen in set proportions such that the patient breathes in a known fraction of inspired oxygen (FiO2). The principal modes of delivery are described below.


Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease.

Brill SE, Wedzicha JA - Int J Chron Obstruct Pulmon Dis (2014)

General principles of titrated oxygen therapy.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230177&req=5

f2-copd-9-1241: General principles of titrated oxygen therapy.
Mentions: The key to achieving appropriate levels of oxygenation is using controlled oxygen therapy, with the patient’s oxygen level monitored and the supplemental oxygen therapy titrated to achieve acceptable saturations. This approach is summarized in Figure 2. Titration can be achieved either by altering the oxygen flow rate or, with certain delivery devices, administering a mixture of air and oxygen in set proportions such that the patient breathes in a known fraction of inspired oxygen (FiO2). The principal modes of delivery are described below.

Bottom Line: Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support.The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suffered by many patients during this high-risk period.We also review current recommendations for best practice, including methods for improving oxygen provision in the future.

View Article: PubMed Central - PubMed

Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK.

ABSTRACT
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the history of this debilitating lung condition. Associated health care utilization and morbidity are high, and many patients require supplemental oxygen or ventilatory support. The last 2 decades have seen a substantial increase in our understanding of the best way to manage the respiratory failure suffered by many patients during this high-risk period. This review article examines the evidence underlying supplemental oxygen therapy during exacerbations of COPD. We first discuss the epidemiology and pathophysiology of respiratory failure in COPD during exacerbations. The rationale and evidence underlying oxygen therapy, including the risks when administered inappropriately, are then discussed, along with further strategies for ventilatory support. We also review current recommendations for best practice, including methods for improving oxygen provision in the future.

Show MeSH
Related in: MedlinePlus