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Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus

Changes in SF-36 scores prior to and after acceleration training in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between baseline and week 12.Abbreviations: BP, bodily pain; GH, general health perception; SF-36, Short Form Health Survey; ER, emotional role; MH, mental health; PF, physical functioning; PR, physical role; SF, social functioning; VT, vitality.
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f4-tcrm-10-925: Changes in SF-36 scores prior to and after acceleration training in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between baseline and week 12.Abbreviations: BP, bodily pain; GH, general health perception; SF-36, Short Form Health Survey; ER, emotional role; MH, mental health; PF, physical functioning; PR, physical role; SF, social functioning; VT, vitality.

Mentions: Eight subscales were used to measure the effect of the AT program on quality of life ie, physical functioning, physical role, bodily pain, emotional role, mental health, general health perception, vitality, and social functioning. Of these, significant improvements were observed in levels of physical functioning (41.6 [32.6–50.6] versus 48.8 [39.8–54.2], P=0.009), physical role (50.8 [42.4–55.7] versus 55.7 [52.4–55.7], P=0.042), general health perception (38.4 [35.1–49.5] versus 46.9 [38.9–49.5], P=0.011), and social functioning (53.8 [37.7–57.0] versus 57.0 [50.6–57.0], P=0.036, Figure 4).


Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Changes in SF-36 scores prior to and after acceleration training in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between baseline and week 12.Abbreviations: BP, bodily pain; GH, general health perception; SF-36, Short Form Health Survey; ER, emotional role; MH, mental health; PF, physical functioning; PR, physical role; SF, social functioning; VT, vitality.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230176&req=5

f4-tcrm-10-925: Changes in SF-36 scores prior to and after acceleration training in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between baseline and week 12.Abbreviations: BP, bodily pain; GH, general health perception; SF-36, Short Form Health Survey; ER, emotional role; MH, mental health; PF, physical functioning; PR, physical role; SF, social functioning; VT, vitality.
Mentions: Eight subscales were used to measure the effect of the AT program on quality of life ie, physical functioning, physical role, bodily pain, emotional role, mental health, general health perception, vitality, and social functioning. Of these, significant improvements were observed in levels of physical functioning (41.6 [32.6–50.6] versus 48.8 [39.8–54.2], P=0.009), physical role (50.8 [42.4–55.7] versus 55.7 [52.4–55.7], P=0.042), general health perception (38.4 [35.1–49.5] versus 46.9 [38.9–49.5], P=0.011), and social functioning (53.8 [37.7–57.0] versus 57.0 [50.6–57.0], P=0.036, Figure 4).

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus