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Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus

Effects of AT on serum levels of leptin, adiponectin, TNF-α, IL-6 (A), and hs-CRP and TBARS (B) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between the baseline and week 12. †P<0.05, ††P<0.01, significant difference between groups (normal subject group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin-6; hsCRP, high-sensitivity C-reactive protein; TBARS, thiobarbituric acid reactive substances.
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f3-tcrm-10-925: Effects of AT on serum levels of leptin, adiponectin, TNF-α, IL-6 (A), and hs-CRP and TBARS (B) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between the baseline and week 12. †P<0.05, ††P<0.01, significant difference between groups (normal subject group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin-6; hsCRP, high-sensitivity C-reactive protein; TBARS, thiobarbituric acid reactive substances.

Mentions: With regard to adipokines, the leptin, TNF-α, and interleukin-6 levels were significantly higher and the adiponectin level was significantly lower in the study subjects than in the controls (Figure 3A). The participants showed a significant improvement in levels of leptin (31.9 [16.9–53.5] versus 28.8 [15.3–36.3] ng/mL, P=0.031), adiponectin (3.69 [2.72–6.24] versus 4.01 [3.29–6.55] ng/mL, P=0.022), TNF-α (1.45 [0.53–2.11] versus 1.19 [0.34–1.82] pg/mL, P=0.012), and interleukin-6 (2.05 [1.81–3.08] versus 1.50 [1.24–2.32] pg/mL, P=0.011, Figure 3A). In contrast, no improvement was observed in the levels of high-sensitivity C-reactive protein (an inflammatory marker) and thiobarbituric acid reactive substances (an oxidative stress marker, Figure 3B).


Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Effects of AT on serum levels of leptin, adiponectin, TNF-α, IL-6 (A), and hs-CRP and TBARS (B) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between the baseline and week 12. †P<0.05, ††P<0.01, significant difference between groups (normal subject group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin-6; hsCRP, high-sensitivity C-reactive protein; TBARS, thiobarbituric acid reactive substances.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230176&req=5

f3-tcrm-10-925: Effects of AT on serum levels of leptin, adiponectin, TNF-α, IL-6 (A), and hs-CRP and TBARS (B) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference between the baseline and week 12. †P<0.05, ††P<0.01, significant difference between groups (normal subject group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin-6; hsCRP, high-sensitivity C-reactive protein; TBARS, thiobarbituric acid reactive substances.
Mentions: With regard to adipokines, the leptin, TNF-α, and interleukin-6 levels were significantly higher and the adiponectin level was significantly lower in the study subjects than in the controls (Figure 3A). The participants showed a significant improvement in levels of leptin (31.9 [16.9–53.5] versus 28.8 [15.3–36.3] ng/mL, P=0.031), adiponectin (3.69 [2.72–6.24] versus 4.01 [3.29–6.55] ng/mL, P=0.022), TNF-α (1.45 [0.53–2.11] versus 1.19 [0.34–1.82] pg/mL, P=0.012), and interleukin-6 (2.05 [1.81–3.08] versus 1.50 [1.24–2.32] pg/mL, P=0.011, Figure 3A). In contrast, no improvement was observed in the levels of high-sensitivity C-reactive protein (an inflammatory marker) and thiobarbituric acid reactive substances (an oxidative stress marker, Figure 3B).

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus