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Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus

Effects of AT on muscle strength (A), cross-sectional area (B), fat deposition (C) in the femoral muscle (quadriceps), intrahepatocellular lipids measured by magnetic resonance spectroscopy (D), intrahepatocellular lipids measured by Fibroscan 502 (E), and liver stiffness (F) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference versus baseline and week 12. †P 0.05, ††P<0.01, significant difference between groups (normal group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; IMCL, intramyocellular lipids; EMCL, extramyocellular lipids; IHL, intrahepatic lipids.
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f2-tcrm-10-925: Effects of AT on muscle strength (A), cross-sectional area (B), fat deposition (C) in the femoral muscle (quadriceps), intrahepatocellular lipids measured by magnetic resonance spectroscopy (D), intrahepatocellular lipids measured by Fibroscan 502 (E), and liver stiffness (F) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference versus baseline and week 12. †P 0.05, ††P<0.01, significant difference between groups (normal group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; IMCL, intramyocellular lipids; EMCL, extramyocellular lipids; IHL, intrahepatic lipids.

Mentions: The participants underwent muscle strength testing before and after the AT program (Figure 2A). A significant increase was observed in median values for strength in the femoral muscles (quadriceps) during isometric knee extension before versus after intervention (1.58 [1.29–1.88] versus 1.78 [1.34–1.97] Nm/kg, P=0.004). In contrast, there was no significant change in the strength of the femoral muscles (hamstrings) during isometric knee flexion (0.64 [0.57–0.73] versus 0.70 [0.62–0.79] Nm/kg, P=0.18). Magnetic resonance imaging analysis of the quadriceps (cross-sectional area) showed a significant increase (55.2 [49.0–64.4] versus 56.9 [46.6–66.7] cm2, P=0.020, Figure 2B). However, there was no significant change in the strength of the hamstrings (22.2 [19.1–28.7] versus 21.9 [19.4–25.9] cm2, P=0.43).


Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Effects of AT on muscle strength (A), cross-sectional area (B), fat deposition (C) in the femoral muscle (quadriceps), intrahepatocellular lipids measured by magnetic resonance spectroscopy (D), intrahepatocellular lipids measured by Fibroscan 502 (E), and liver stiffness (F) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference versus baseline and week 12. †P 0.05, ††P<0.01, significant difference between groups (normal group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; IMCL, intramyocellular lipids; EMCL, extramyocellular lipids; IHL, intrahepatic lipids.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230176&req=5

f2-tcrm-10-925: Effects of AT on muscle strength (A), cross-sectional area (B), fat deposition (C) in the femoral muscle (quadriceps), intrahepatocellular lipids measured by magnetic resonance spectroscopy (D), intrahepatocellular lipids measured by Fibroscan 502 (E), and liver stiffness (F) in obese patients with nonalcoholic fatty liver disease.Notes: *P<0.05, significant difference versus baseline and week 12. †P 0.05, ††P<0.01, significant difference between groups (normal group versus AT group pre and post). The lower edge, midline, and upper edge of each box represent the 25th percentile, median, and 75th percentile scores, respectively. The line from each box extends to the minimum and maximum score.Abbreviations: AT, acceleration training; IMCL, intramyocellular lipids; EMCL, extramyocellular lipids; IHL, intrahepatic lipids.
Mentions: The participants underwent muscle strength testing before and after the AT program (Figure 2A). A significant increase was observed in median values for strength in the femoral muscles (quadriceps) during isometric knee extension before versus after intervention (1.58 [1.29–1.88] versus 1.78 [1.34–1.97] Nm/kg, P=0.004). In contrast, there was no significant change in the strength of the femoral muscles (hamstrings) during isometric knee flexion (0.64 [0.57–0.73] versus 0.70 [0.62–0.79] Nm/kg, P=0.18). Magnetic resonance imaging analysis of the quadriceps (cross-sectional area) showed a significant increase (55.2 [49.0–64.4] versus 56.9 [46.6–66.7] cm2, P=0.020, Figure 2B). However, there was no significant change in the strength of the hamstrings (22.2 [19.1–28.7] versus 21.9 [19.4–25.9] cm2, P=0.43).

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus