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Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus

Illustration of the synchronous mode of vibration transmission in whole-body vibration exercise. Both legs extend and stretch at the same time, and a purely linear acceleration is directed to the trunk.
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f1-tcrm-10-925: Illustration of the synchronous mode of vibration transmission in whole-body vibration exercise. Both legs extend and stretch at the same time, and a purely linear acceleration is directed to the trunk.

Mentions: A new training method, termed whole-body vibration (WBV), has recently been introduced. This method employs equipment with a platform that vibrates at high speed and low amplitude.10 The principle behind WBV is that energy generated by the vibration device is transferred to the human body as a resonator. Mechanical oscillations of the vibration device have a sinusoidal shape, and the vibration acceleration (m/s2) and gravitational acceleration (G; 1G =9.81 m/s2) are determined by adjusting frequency (Hz) and amplitude (mm). On the WBV platform, a load corresponding to the product of body weight and gravity plus vibration acceleration is placed on the body (Figure 1). The vibration device generates three-dimensional vibrations in the vertical (z), frontal (x), and sagittal (y) directions. The acceleration in the vertical direction is considered to be the most effective component in inducing beneficial effects on the human body. Many ongoing studies are analyzing the effectiveness of WBV in subjects of different ages, health states, and physical activity levels.


Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.

Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J - Ther Clin Risk Manag (2014)

Illustration of the synchronous mode of vibration transmission in whole-body vibration exercise. Both legs extend and stretch at the same time, and a purely linear acceleration is directed to the trunk.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4230176&req=5

f1-tcrm-10-925: Illustration of the synchronous mode of vibration transmission in whole-body vibration exercise. Both legs extend and stretch at the same time, and a purely linear acceleration is directed to the trunk.
Mentions: A new training method, termed whole-body vibration (WBV), has recently been introduced. This method employs equipment with a platform that vibrates at high speed and low amplitude.10 The principle behind WBV is that energy generated by the vibration device is transferred to the human body as a resonator. Mechanical oscillations of the vibration device have a sinusoidal shape, and the vibration acceleration (m/s2) and gravitational acceleration (G; 1G =9.81 m/s2) are determined by adjusting frequency (Hz) and amplitude (mm). On the WBV platform, a load corresponding to the product of body weight and gravity plus vibration acceleration is placed on the body (Figure 1). The vibration device generates three-dimensional vibrations in the vertical (z), frontal (x), and sagittal (y) directions. The acceleration in the vertical direction is considered to be the most effective component in inducing beneficial effects on the human body. Many ongoing studies are analyzing the effectiveness of WBV in subjects of different ages, health states, and physical activity levels.

Bottom Line: Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration.Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%).On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan.

ABSTRACT

Background: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.

Methods: A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.

Results: During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (-26.4%). Notably, they showed a modest reduction in body weight (-1.9%), abdominal visceral fat area (-3.4%), and hepatic fat content (-8.7%), coupled with a significant reduction in levels of aminotransferase (-15.7%), γ-glutamyltransferase (-14.4%), leptin (-9.7%), interleukin-6 (-26.8%), and tumor necrosis factor-α (-17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).

Conclusion: AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

No MeSH data available.


Related in: MedlinePlus