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Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala.

Chen L, Yang Y, Yuan P, Yang Y, Chen K, Jia Q, Li Y - Evid Based Complement Alternat Med (2014)

Bottom Line: Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear.Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1.CTD-1 dose-dependently reduced the level of IFN-γ and IL-2 and intensively suppressed DNFB-induced DTH responses.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China.

ABSTRACT
Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear. The aim of this study is to find out the possible component(s) that can be used as therapeutic agents for immune-related diseases from cinnamon bark. In this study, the immunosuppressive effects of fraction (named CT-F) and five procyanidin oligomers compounds, cinnamtannin B1, cinnamtannin D1 (CTD-1), parameritannin A1, procyanidin B2, and procyanidin C1, from Cinnamomum tamala or Cinnamomum cassia bark were examined on splenocytes proliferation model induced by ConA or LPS. Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1. It was found that CT-F and CTD-1 significantly inhibited the splenocyte proliferation induced by ConA or LPS. CTD-1 dose-dependently reduced the level of IFN-γ and IL-2 and intensively suppressed DNFB-induced DTH responses. These findings suggest that the immunosuppressive activities of cinnamon bark are in part due to procyanidin oligomers. CTD-1 may be a potential therapeutic agent for immune-related diseases.

No MeSH data available.


Related in: MedlinePlus

RP-HPLC chromatographic profile of procyanidin oligomers of CT-F, detected at 280 nm. 1: PA-1, 2: PB-2, 3: CTD-1, 4: CTB-1, 5: PC-1, and 6-7: A-type procyanidin trimers.
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fig2: RP-HPLC chromatographic profile of procyanidin oligomers of CT-F, detected at 280 nm. 1: PA-1, 2: PB-2, 3: CTD-1, 4: CTB-1, 5: PC-1, and 6-7: A-type procyanidin trimers.

Mentions: As shown in Figure 2, the retention time values of the main chromatographic peaks in CT-F were at 6.7, 9.2, 11.2, 12.7, 13.4, 15.6, and 17.4 min. These peaks were marked as 1 to 7. In comparison to the reference compounds isolated from two cinnamon barks, the peaks were identified as follows: 1 was PA-1; 2 was PB-2; 3 was CTD-1; 4 was CTB-1; 5 was PC-1. Peaks 6 and 7 were identified as A-type procyanidin trimers according to ESI-MS data that showed the presence of molecular ions at m/z 863 in the negative ion mode (Supplementary Material). Hence, CT-F may primarily contain A-type procyanidin because the main peaks in CT-F were CTD-1 and CTB-1, which are A-type procyanidin trimers.


Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala.

Chen L, Yang Y, Yuan P, Yang Y, Chen K, Jia Q, Li Y - Evid Based Complement Alternat Med (2014)

RP-HPLC chromatographic profile of procyanidin oligomers of CT-F, detected at 280 nm. 1: PA-1, 2: PB-2, 3: CTD-1, 4: CTB-1, 5: PC-1, and 6-7: A-type procyanidin trimers.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4230008&req=5

fig2: RP-HPLC chromatographic profile of procyanidin oligomers of CT-F, detected at 280 nm. 1: PA-1, 2: PB-2, 3: CTD-1, 4: CTB-1, 5: PC-1, and 6-7: A-type procyanidin trimers.
Mentions: As shown in Figure 2, the retention time values of the main chromatographic peaks in CT-F were at 6.7, 9.2, 11.2, 12.7, 13.4, 15.6, and 17.4 min. These peaks were marked as 1 to 7. In comparison to the reference compounds isolated from two cinnamon barks, the peaks were identified as follows: 1 was PA-1; 2 was PB-2; 3 was CTD-1; 4 was CTB-1; 5 was PC-1. Peaks 6 and 7 were identified as A-type procyanidin trimers according to ESI-MS data that showed the presence of molecular ions at m/z 863 in the negative ion mode (Supplementary Material). Hence, CT-F may primarily contain A-type procyanidin because the main peaks in CT-F were CTD-1 and CTB-1, which are A-type procyanidin trimers.

Bottom Line: Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear.Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1.CTD-1 dose-dependently reduced the level of IFN-γ and IL-2 and intensively suppressed DNFB-induced DTH responses.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China.

ABSTRACT
Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear. The aim of this study is to find out the possible component(s) that can be used as therapeutic agents for immune-related diseases from cinnamon bark. In this study, the immunosuppressive effects of fraction (named CT-F) and five procyanidin oligomers compounds, cinnamtannin B1, cinnamtannin D1 (CTD-1), parameritannin A1, procyanidin B2, and procyanidin C1, from Cinnamomum tamala or Cinnamomum cassia bark were examined on splenocytes proliferation model induced by ConA or LPS. Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1. It was found that CT-F and CTD-1 significantly inhibited the splenocyte proliferation induced by ConA or LPS. CTD-1 dose-dependently reduced the level of IFN-γ and IL-2 and intensively suppressed DNFB-induced DTH responses. These findings suggest that the immunosuppressive activities of cinnamon bark are in part due to procyanidin oligomers. CTD-1 may be a potential therapeutic agent for immune-related diseases.

No MeSH data available.


Related in: MedlinePlus