A comparison of estimated glomerular filtration rates using Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration estimating equations in HIV infection.
Bottom Line: Differences between CKD-EPI and CG were much greater when CG was not standardized for body surface area (BSA).A total of 403 persons developed moderate CKD using CG [incidence 8.9/1000 person-years of follow-up (PYFU); 95% confidence interval (CI) 8.0-9.8] and 364 using CKD-EPI (incidence 7.3/1000 PYFU; 95% CI 6.5-8.0).In the absence of a gold standard, the two formulae predicted clinical outcomes with equal precision and can be used to estimate GFR in HIV-positive persons.
Affiliation: Department of Infection and Population Health, University College London, London, UK.Show MeSH
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Mentions: There were 36 persons who developed ESRD or who died from renal disease (incidence rate 0.7/1000 PYFU; 95% CI 0.5–0.9) and 565 deaths (incidence 10.8/1000 PYFU; 95% CI 9.9–11.7) during prospective follow-up. CG-derived eGFRs were equal to CKD-EPI-derived eGFRs at predicting both ESRD and death, as measured by a lower Akaike information criterion and log-likelihood, summarized in Figure 2. After adjustment, CG-derived moderate and advanced CKDs were associated with ESRD [adjusted incidence rate ratio (aIRR) 7.17; 95% CI 2.65–19.36 and aIRR 23.46; 95% CI 8.54–64.48, respectively], as were CKD-EPI-derived moderate and advanced CKDs (aIRR 12.41; 95% CI 4.74–32.51 and aIRR 12.44; 95% CI 4.83–32.03, respectively). CG-derived moderate CKD but not advanced CKD was associated with all-cause mortality (aIRR 1.45; 95% CI 1.11–1.90 and aIRR 1.52; 95% CI 0.87–2.67, respectively), while CKD-EPI-derived moderate CKD was not significantly associated with all-cause mortality, but advanced CKD was (aIRR 1.12; 95% CI 0.84–1.50 and aIRR 2.08; 95% CI 1.22–3.57, respectively).
Affiliation: Department of Infection and Population Health, University College London, London, UK.