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Targetoid hemosiderotic hemangioma.

Gutte RM, Joshi A - Indian Dermatol Online J (2014)

View Article: PubMed Central - PubMed

Affiliation: Departments of Dermatology, Surgery, Dr. L. H. Hiranandani Hospital, Powai, Mumbai, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
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Physical examination showed a raised blackish compressible papule over the anterior aspect of the left thigh, 0.5 cm in diameter, surrounded by a peripheral purpuric ring with a few pale areas [Figure 1]... A sparse lymphohistiocytic infiltrate was noted at the base of lesion... At higher magnification, the vessels were found to be lined by a single layer of endothelial cells with no papillary projections protruding into the lumen... The classic clinical presentation of THH is that of a single, annular, targetoid-appearing lesion made up of a violaceous papule surrounded by an ecchymotic ring... These lesions are generally less than 1 cm in diameter... The clinical presentation may not always be as characteristic as seen in present case... Clinical differential diagnoses include melanocytic lesions, infantile hemangioma, tufted angioma, Kaposi sarcoma, insect bite, erythema multiforme, and dermatofibroma, depending on the stage of evolution... The histological differential diagnoses include early Kaposi's sarcoma, epithelioid hemangioma, progressive lymphangioma, and well-differentiated angiosarcoma... Late lesions have been described as showing collapsed vascular lumina, fibrosis, and abundant hemosiderin... Findings in the present case were consistent with late lesion... The lymphatic endothelial cell marker D2-40 (podoplanin) has been found strongly positive in most of the case series... Thus THH has recently been shown to be a lymphatic malformation.

No MeSH data available.


Related in: MedlinePlus

Well-circumscribed vascular proliferation in papillary dermis and extending into upper reticular dermis (H and E, ×40)
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Figure 2: Well-circumscribed vascular proliferation in papillary dermis and extending into upper reticular dermis (H and E, ×40)

Mentions: A 30-year-old male presented with an asymptomatic erythematous patch over his left thigh of five years duration with an evolving central blackish growth over the same patch since the last six months. There was no history of any trauma preceding the lesion. Physical examination showed a raised blackish compressible papule over the anterior aspect of the left thigh, 0.5 cm in diameter, surrounded by a peripheral purpuric ring with a few pale areas [Figure 1]. There was no other cutaneous or systemic abnormality. Excision biopsy showed vascular proliferation with dilated and bizarre-shaped vessels in the papillary dermis and extending into the upper reticular dermis. Numerous extravasated erythrocytes were present between collagen bundles. A sparse lymphohistiocytic infiltrate was noted at the base of lesion. At higher magnification, the vessels were found to be lined by a single layer of endothelial cells with no papillary projections protruding into the lumen. Deposition of hemosiderin, though noted throughout, was more pronounced in areas of extravasation of erythrocytes [Figure 2 and 3].


Targetoid hemosiderotic hemangioma.

Gutte RM, Joshi A - Indian Dermatol Online J (2014)

Well-circumscribed vascular proliferation in papillary dermis and extending into upper reticular dermis (H and E, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4228682&req=5

Figure 2: Well-circumscribed vascular proliferation in papillary dermis and extending into upper reticular dermis (H and E, ×40)
Mentions: A 30-year-old male presented with an asymptomatic erythematous patch over his left thigh of five years duration with an evolving central blackish growth over the same patch since the last six months. There was no history of any trauma preceding the lesion. Physical examination showed a raised blackish compressible papule over the anterior aspect of the left thigh, 0.5 cm in diameter, surrounded by a peripheral purpuric ring with a few pale areas [Figure 1]. There was no other cutaneous or systemic abnormality. Excision biopsy showed vascular proliferation with dilated and bizarre-shaped vessels in the papillary dermis and extending into the upper reticular dermis. Numerous extravasated erythrocytes were present between collagen bundles. A sparse lymphohistiocytic infiltrate was noted at the base of lesion. At higher magnification, the vessels were found to be lined by a single layer of endothelial cells with no papillary projections protruding into the lumen. Deposition of hemosiderin, though noted throughout, was more pronounced in areas of extravasation of erythrocytes [Figure 2 and 3].

View Article: PubMed Central - PubMed

Affiliation: Departments of Dermatology, Surgery, Dr. L. H. Hiranandani Hospital, Powai, Mumbai, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Physical examination showed a raised blackish compressible papule over the anterior aspect of the left thigh, 0.5 cm in diameter, surrounded by a peripheral purpuric ring with a few pale areas [Figure 1]... A sparse lymphohistiocytic infiltrate was noted at the base of lesion... At higher magnification, the vessels were found to be lined by a single layer of endothelial cells with no papillary projections protruding into the lumen... The classic clinical presentation of THH is that of a single, annular, targetoid-appearing lesion made up of a violaceous papule surrounded by an ecchymotic ring... These lesions are generally less than 1 cm in diameter... The clinical presentation may not always be as characteristic as seen in present case... Clinical differential diagnoses include melanocytic lesions, infantile hemangioma, tufted angioma, Kaposi sarcoma, insect bite, erythema multiforme, and dermatofibroma, depending on the stage of evolution... The histological differential diagnoses include early Kaposi's sarcoma, epithelioid hemangioma, progressive lymphangioma, and well-differentiated angiosarcoma... Late lesions have been described as showing collapsed vascular lumina, fibrosis, and abundant hemosiderin... Findings in the present case were consistent with late lesion... The lymphatic endothelial cell marker D2-40 (podoplanin) has been found strongly positive in most of the case series... Thus THH has recently been shown to be a lymphatic malformation.

No MeSH data available.


Related in: MedlinePlus