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Bio-conjugated polycaprolactone membranes: a novel wound dressing.

Cai EZ, Teo EY, Jing L, Koh YP, Qian TS, Wen F, Lee JW, Hing EC, Yap YL, Lee H, Lee CN, Teoh SH, Lim J, Lim TC - Arch Plast Surg (2014)

Bottom Line: Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue.There was no significant difference (P>0.05) in wound size between the two groups.BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National University Health System, Singapore.

ABSTRACT

Background: The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.

Methods: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.

Results: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.

Conclusions: BPM is comparable to Mepitel as a safe and efficacious wound dressing.

No MeSH data available.


Related in: MedlinePlus

Graph of wound sizeA decreasing trend in wound area can been observed in both groups. PCL, polycaprolactone.
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Figure 6: Graph of wound sizeA decreasing trend in wound area can been observed in both groups. PCL, polycaprolactone.

Mentions: A gradual reduction in the wound area was seen in both the treatment group (bio-conjugated PCL membrane) and the control group (Mepitel) over 28 days (Fig. 6). Throughout the study, there was no statistical difference observed between the wound size of the control group and treatment group. From day 7 onwards, the wound area decreased sharply to approximately 40% of its original area by day 14. At 28 days, the wounds from both groups had achieved an average of 84% wound contracture (Fig. 7).


Bio-conjugated polycaprolactone membranes: a novel wound dressing.

Cai EZ, Teo EY, Jing L, Koh YP, Qian TS, Wen F, Lee JW, Hing EC, Yap YL, Lee H, Lee CN, Teoh SH, Lim J, Lim TC - Arch Plast Surg (2014)

Graph of wound sizeA decreasing trend in wound area can been observed in both groups. PCL, polycaprolactone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4228204&req=5

Figure 6: Graph of wound sizeA decreasing trend in wound area can been observed in both groups. PCL, polycaprolactone.
Mentions: A gradual reduction in the wound area was seen in both the treatment group (bio-conjugated PCL membrane) and the control group (Mepitel) over 28 days (Fig. 6). Throughout the study, there was no statistical difference observed between the wound size of the control group and treatment group. From day 7 onwards, the wound area decreased sharply to approximately 40% of its original area by day 14. At 28 days, the wounds from both groups had achieved an average of 84% wound contracture (Fig. 7).

Bottom Line: Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue.There was no significant difference (P>0.05) in wound size between the two groups.BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National University Health System, Singapore.

ABSTRACT

Background: The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.

Methods: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.

Results: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.

Conclusions: BPM is comparable to Mepitel as a safe and efficacious wound dressing.

No MeSH data available.


Related in: MedlinePlus