Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans.
Bottom Line: We have developed organic acid-modified Fe(III) oxo-hydroxide nanomaterials, here termed nano Fe(III), as alternative safe iron delivery agents.Furthermore, IHAT did not accumulate in the intestinal mucosa and, unlike Fe(II) sulfate, promoted a beneficial microbiota.Out of the tested preparations, iron hydroxide adipate tartrate met the above criteria, and may become an important tool in addressing this common condition.
Affiliation: MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: Using the gold standard measurement of isotopic incorporation into haemoglobin we confirmed that, as previously reported in human and rodent feeding studies,23,37,38 Fe(III) oxo-hydroxide that had not been ligand-modified (i.e. unmodified synthetic ferrihydrite) was poorly absorbed/utilised in iron deficient subjects [P < 0.0001 versus Fe(II) sulfate]. Its bioavailability was 5-fold lower than the average of the ligand-modified nano Fe(III) materials (Figure 2, A).
Affiliation: MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom. Electronic address: email@example.com.