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Low-magnitude high-frequency loading, by whole-body vibration, accelerates early implant osseointegration in ovariectomized rats.

Liang YQ, Qi MC, Xu J, Xu J, Liu HW, Dong W, Li JY, Hu M - Mol Med Rep (2014)

Bottom Line: LMHF loading via whole‑body vibration (WBV) for 8 weeks has previously been demonstrated to significantly enhance bone‑to‑implant contact, peri‑implant bone fraction and implant mechanical properties in osteoporotic rats.In the present study, LMHF loading by WBV was performed in osteoporotic rats, with a loading duration of 4 weeks during the early stages of bone healing.The results indicated that 4‑week LMHF loading by WBV partly reversed the negative effects of osteoporosis and accelerated early peri‑implant osseointegration in ovariectomized rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, P.R. China.

ABSTRACT
Osteoporosis deteriorates jaw bone quality and may compromise early implant osseointegration and early implant loading. The influence of low‑magnitude, high‑frequency (LMHF) vibration on peri‑implant bone healing and implant integration in osteoporotic bones remains poorly understood. LMHF loading via whole‑body vibration (WBV) for 8 weeks has previously been demonstrated to significantly enhance bone‑to‑implant contact, peri‑implant bone fraction and implant mechanical properties in osteoporotic rats. In the present study, LMHF loading by WBV was performed in osteoporotic rats, with a loading duration of 4 weeks during the early stages of bone healing. The results indicated that 4‑week LMHF loading by WBV partly reversed the negative effects of osteoporosis and accelerated early peri‑implant osseointegration in ovariectomized rats.

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Related in: MedlinePlus

(A) X-ray demonstrating insertion of titanium implant in the proximal metaphysis of the tibia and (B) the vibrating device.
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f1-mmr-10-06-2835: (A) X-ray demonstrating insertion of titanium implant in the proximal metaphysis of the tibia and (B) the vibrating device.

Mentions: Four weeks after ovariectomy (20), all animals received a bilateral insertion of implants in the proximal metaphyses of their tibiae under general anesthesia. The implants used were custom-made screw-type titanium implants (Ø2×7 mm) processed from a titanium rod (99.8% Ti; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China) and no surface modification was made. Briefly, incisions (10 mm in length) were made at the bilateral proximal metaphyses of the tibiae, and implantation holes (~1.9 mm in diameter) were drilled with a dental bur (Strong204, Seashin Precision Industrial Co., Taegu, South Korea) under constant saline irrigation. The implants were then screwed into the holes (Fig. 1A) and the soft tissues were sutured in layers. Analgesia and prophylactic antibiotics were also administrated to the animals, as described.


Low-magnitude high-frequency loading, by whole-body vibration, accelerates early implant osseointegration in ovariectomized rats.

Liang YQ, Qi MC, Xu J, Xu J, Liu HW, Dong W, Li JY, Hu M - Mol Med Rep (2014)

(A) X-ray demonstrating insertion of titanium implant in the proximal metaphysis of the tibia and (B) the vibrating device.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4227418&req=5

f1-mmr-10-06-2835: (A) X-ray demonstrating insertion of titanium implant in the proximal metaphysis of the tibia and (B) the vibrating device.
Mentions: Four weeks after ovariectomy (20), all animals received a bilateral insertion of implants in the proximal metaphyses of their tibiae under general anesthesia. The implants used were custom-made screw-type titanium implants (Ø2×7 mm) processed from a titanium rod (99.8% Ti; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China) and no surface modification was made. Briefly, incisions (10 mm in length) were made at the bilateral proximal metaphyses of the tibiae, and implantation holes (~1.9 mm in diameter) were drilled with a dental bur (Strong204, Seashin Precision Industrial Co., Taegu, South Korea) under constant saline irrigation. The implants were then screwed into the holes (Fig. 1A) and the soft tissues were sutured in layers. Analgesia and prophylactic antibiotics were also administrated to the animals, as described.

Bottom Line: LMHF loading via whole‑body vibration (WBV) for 8 weeks has previously been demonstrated to significantly enhance bone‑to‑implant contact, peri‑implant bone fraction and implant mechanical properties in osteoporotic rats.In the present study, LMHF loading by WBV was performed in osteoporotic rats, with a loading duration of 4 weeks during the early stages of bone healing.The results indicated that 4‑week LMHF loading by WBV partly reversed the negative effects of osteoporosis and accelerated early peri‑implant osseointegration in ovariectomized rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, P.R. China.

ABSTRACT
Osteoporosis deteriorates jaw bone quality and may compromise early implant osseointegration and early implant loading. The influence of low‑magnitude, high‑frequency (LMHF) vibration on peri‑implant bone healing and implant integration in osteoporotic bones remains poorly understood. LMHF loading via whole‑body vibration (WBV) for 8 weeks has previously been demonstrated to significantly enhance bone‑to‑implant contact, peri‑implant bone fraction and implant mechanical properties in osteoporotic rats. In the present study, LMHF loading by WBV was performed in osteoporotic rats, with a loading duration of 4 weeks during the early stages of bone healing. The results indicated that 4‑week LMHF loading by WBV partly reversed the negative effects of osteoporosis and accelerated early peri‑implant osseointegration in ovariectomized rats.

Show MeSH
Related in: MedlinePlus