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Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy.

Wojciechowska C, Romuk E, Tomasik A, Skrzep-Poloczek B, Nowalany-Kozielska E, Birkner E, Jacheć W - Mediators Inflamm. (2014)

Bottom Line: MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls.There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation.Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Cardiology, School of Medicine with the Division of Dentistry, Medical University of Silesia, M. C. Skłodowskiej 10 Street, 41-800 Zabrze, Poland.

ABSTRACT

Background: The aim of study was to determine relationships between functional capacity (NYHA class), left ventricle ejection fraction (LVEF), hemodynamic parameters, and biomarkers of redox state and inflammation in patients with dilated cardiomyopathy (DCM).

Methods: DCM patients (n = 109, aged 45.97 ± 10.82 years), NYHA class IIV, and LVEF 2.94 ± 7.1% were studied. Controls comprised age-matched healthy volunteers (n = 28). Echocardiography and right heart catheterization were performed. Serum activities of superoxide dismutase isoenzymes (MnSOD and CuZnSOD), concentrations of uric acid (UA), malondialdehyde (MDA), and C-reactive protein (hs-CRP) were measured.

Results: MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls. Except MDA concentration, above parameters were higher in patients in III-IV NYHA class or with lower LVEF. hsCRP correlated with of MnSOD (P < 0.05) and CuZnSOD activity (P < 0.01). Both isoenzymes positively correlated with mPAP and pulmonary capillary wedge pressure (MnSOD, resp., P < 0.01 and P < 0.05 and CuZnSOD P < 0.05; P < 0.05). UA positively correlated with MnSOD (P < 0.05), mPAP (P < 0.05), and PVRI (P < 0.05). The negative correlation between LVEF and UA (P < 0.01) was detected.

Conclusion: There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation. Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.

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Related in: MedlinePlus

Redox and inflammation biomarkers in patients with LVEF ≥20%, <20%, and control. Median [25%–75%] and 1.5IQR.
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fig2: Redox and inflammation biomarkers in patients with LVEF ≥20%, <20%, and control. Median [25%–75%] and 1.5IQR.

Mentions: Patients group B1 (lower LVEF) had significantly higher concentration of UA, hs-CRP and activity of both izoenzymes SOD in comparison to patients from group A1. MDA concentration was comparable (Figure 2). Except CuZnSOD, patients in B1 group had higher values of examined biomarkers than control (Figure 2, Table 4).


Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy.

Wojciechowska C, Romuk E, Tomasik A, Skrzep-Poloczek B, Nowalany-Kozielska E, Birkner E, Jacheć W - Mediators Inflamm. (2014)

Redox and inflammation biomarkers in patients with LVEF ≥20%, <20%, and control. Median [25%–75%] and 1.5IQR.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4226178&req=5

fig2: Redox and inflammation biomarkers in patients with LVEF ≥20%, <20%, and control. Median [25%–75%] and 1.5IQR.
Mentions: Patients group B1 (lower LVEF) had significantly higher concentration of UA, hs-CRP and activity of both izoenzymes SOD in comparison to patients from group A1. MDA concentration was comparable (Figure 2). Except CuZnSOD, patients in B1 group had higher values of examined biomarkers than control (Figure 2, Table 4).

Bottom Line: MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls.There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation.Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Cardiology, School of Medicine with the Division of Dentistry, Medical University of Silesia, M. C. Skłodowskiej 10 Street, 41-800 Zabrze, Poland.

ABSTRACT

Background: The aim of study was to determine relationships between functional capacity (NYHA class), left ventricle ejection fraction (LVEF), hemodynamic parameters, and biomarkers of redox state and inflammation in patients with dilated cardiomyopathy (DCM).

Methods: DCM patients (n = 109, aged 45.97 ± 10.82 years), NYHA class IIV, and LVEF 2.94 ± 7.1% were studied. Controls comprised age-matched healthy volunteers (n = 28). Echocardiography and right heart catheterization were performed. Serum activities of superoxide dismutase isoenzymes (MnSOD and CuZnSOD), concentrations of uric acid (UA), malondialdehyde (MDA), and C-reactive protein (hs-CRP) were measured.

Results: MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls. Except MDA concentration, above parameters were higher in patients in III-IV NYHA class or with lower LVEF. hsCRP correlated with of MnSOD (P < 0.05) and CuZnSOD activity (P < 0.01). Both isoenzymes positively correlated with mPAP and pulmonary capillary wedge pressure (MnSOD, resp., P < 0.01 and P < 0.05 and CuZnSOD P < 0.05; P < 0.05). UA positively correlated with MnSOD (P < 0.05), mPAP (P < 0.05), and PVRI (P < 0.05). The negative correlation between LVEF and UA (P < 0.01) was detected.

Conclusion: There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation. Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.

Show MeSH
Related in: MedlinePlus