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Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK.

Dominiak-Felden G, Cohet C, Atrux-Tallau S, Gilet H, Tristram A, Fiander A - BMC Public Health (2013)

Bottom Line: A significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW.VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, Sanofi Pasteur MSD, Lyon, France. GDominiak-Felden@spmsd.com.

ABSTRACT

Background: Data on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives of this study were to measure and compare the psychosocial burden and the impact on health-related quality of life (HRQoL) of HPV-related lower genital tract diseases and genital warts (GW) using several generic and disease-specific instruments.

Methods: Overall, 842 individuals with normal cervical cytology (n = 241), borderline nuclear abnormalities and/or mild dyskaryosis (n = 23), cervical intraepithelial neoplasia (CIN)1 (n = 84), CIN2/3 (n = 203), vulval intraepithelial neoplasia (VIN)2/3 (n = 43), GW (n = 186) and a history of GW (non-current) (n = 62) were included. The generic European Quality of Life Index Version 5D (EQ-5D) questionnaire was completed by patients with GW and VIN2/3. Sexual functioning was evaluated using the Change in Sexual Functioning Questionnaire (CSFQ). Psychosocial impact was measured in women using the HPV Impact Profile (HIP) questionnaire. HRQoL was assessed using a GW-specific questionnaire, the Cuestionario Especifico en Condilomas Acuminados (CECA) (completed by patients with GW and history of GW). For each instrument, scores were compared between groups using the Student's t-test. In addition, utility loss due to GW and VIN2/3 was evaluated by comparing mean EQ-5D scores weighted by age and sex with the UK general population normal values.

Results: A significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW. The health state of younger adults with GW was significantly impaired compared with UK normal values (mean EQ-5D index score 0.86 vs 0.94, p < 0.001 for 18-24-year-olds; 0.87 vs 0.93, p = 0.030 for 25-34-year-olds). VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).

Conclusions: HPV-related lower genital tract lesions and GW significantly impair psychosocial wellbeing and HRQoL. The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

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Related in: MedlinePlus

Analysis of CECA scores (crude data). (a) Comparison of mean CECA scores for male and female participants with GW versus those with a history of GW. (b) Comparison of mean CECA scores for women and (c) for men with GW versus those with a history of GW. Higher scores indicate a better health-related quality of life. p values are from the Student’s t-test and compare the GW group with the history of GW group. Error bars represent standard error of the mean. CECA, Cuestionario Especifico en Condilomas Acuminados; GW, genital warts.
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Figure 4: Analysis of CECA scores (crude data). (a) Comparison of mean CECA scores for male and female participants with GW versus those with a history of GW. (b) Comparison of mean CECA scores for women and (c) for men with GW versus those with a history of GW. Higher scores indicate a better health-related quality of life. p values are from the Student’s t-test and compare the GW group with the history of GW group. Error bars represent standard error of the mean. CECA, Cuestionario Especifico en Condilomas Acuminados; GW, genital warts.

Mentions: Overall, participants with current GW had significantly lower mean CECA emotional, sexual and global scores than participants with a history of GW (non-current) (p = 0.008, p = 0.020 and p = 0.006, respectively; Figure 4a). After stratification by sex, similar differences were observed in women (Figure 4b) but not in men (Figure 4c).


Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK.

Dominiak-Felden G, Cohet C, Atrux-Tallau S, Gilet H, Tristram A, Fiander A - BMC Public Health (2013)

Analysis of CECA scores (crude data). (a) Comparison of mean CECA scores for male and female participants with GW versus those with a history of GW. (b) Comparison of mean CECA scores for women and (c) for men with GW versus those with a history of GW. Higher scores indicate a better health-related quality of life. p values are from the Student’s t-test and compare the GW group with the history of GW group. Error bars represent standard error of the mean. CECA, Cuestionario Especifico en Condilomas Acuminados; GW, genital warts.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225724&req=5

Figure 4: Analysis of CECA scores (crude data). (a) Comparison of mean CECA scores for male and female participants with GW versus those with a history of GW. (b) Comparison of mean CECA scores for women and (c) for men with GW versus those with a history of GW. Higher scores indicate a better health-related quality of life. p values are from the Student’s t-test and compare the GW group with the history of GW group. Error bars represent standard error of the mean. CECA, Cuestionario Especifico en Condilomas Acuminados; GW, genital warts.
Mentions: Overall, participants with current GW had significantly lower mean CECA emotional, sexual and global scores than participants with a history of GW (non-current) (p = 0.008, p = 0.020 and p = 0.006, respectively; Figure 4a). After stratification by sex, similar differences were observed in women (Figure 4b) but not in men (Figure 4c).

Bottom Line: A significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW.VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, Sanofi Pasteur MSD, Lyon, France. GDominiak-Felden@spmsd.com.

ABSTRACT

Background: Data on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives of this study were to measure and compare the psychosocial burden and the impact on health-related quality of life (HRQoL) of HPV-related lower genital tract diseases and genital warts (GW) using several generic and disease-specific instruments.

Methods: Overall, 842 individuals with normal cervical cytology (n = 241), borderline nuclear abnormalities and/or mild dyskaryosis (n = 23), cervical intraepithelial neoplasia (CIN)1 (n = 84), CIN2/3 (n = 203), vulval intraepithelial neoplasia (VIN)2/3 (n = 43), GW (n = 186) and a history of GW (non-current) (n = 62) were included. The generic European Quality of Life Index Version 5D (EQ-5D) questionnaire was completed by patients with GW and VIN2/3. Sexual functioning was evaluated using the Change in Sexual Functioning Questionnaire (CSFQ). Psychosocial impact was measured in women using the HPV Impact Profile (HIP) questionnaire. HRQoL was assessed using a GW-specific questionnaire, the Cuestionario Especifico en Condilomas Acuminados (CECA) (completed by patients with GW and history of GW). For each instrument, scores were compared between groups using the Student's t-test. In addition, utility loss due to GW and VIN2/3 was evaluated by comparing mean EQ-5D scores weighted by age and sex with the UK general population normal values.

Results: A significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW. The health state of younger adults with GW was significantly impaired compared with UK normal values (mean EQ-5D index score 0.86 vs 0.94, p < 0.001 for 18-24-year-olds; 0.87 vs 0.93, p = 0.030 for 25-34-year-olds). VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).

Conclusions: HPV-related lower genital tract lesions and GW significantly impair psychosocial wellbeing and HRQoL. The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

Show MeSH
Related in: MedlinePlus