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Brain responses to body image stimuli but not food are altered in women with bulimia nervosa.

Van den Eynde F, Giampietro V, Simmons A, Uher R, Andrew CM, Harvey PO, Campbell IC, Schmidt U - BMC Psychiatry (2013)

Bottom Line: Brain activation patterns in response to food cues did not differ between women with and without BN.However, when evaluating themselves against images of slim women, BN patients engaged the insula more and the fusiform gyrus less, compared to HCs, suggesting increased self-focus among women with BN whilst comparing themselves to a 'slim ideal'.Our findings suggest that women with BN differ from HCs in the way they process body image, but not in the way they process food stimuli.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King's College London, London, UK. Frederique.vandeneynde@mcgill.ca.

ABSTRACT

Background: Research into the neural correlates of bulimia nervosa (BN) psychopathology remains limited.

Methods: In this functional magnetic resonance imaging study, 21 BN patients and 23 healthy controls (HCs) completed two paradigms: (1) processing of visual food stimuli and (2) comparing their own appearance with that of slim women. Participants also rated food craving and anxiety levels.

Results: Brain activation patterns in response to food cues did not differ between women with and without BN. However, when evaluating themselves against images of slim women, BN patients engaged the insula more and the fusiform gyrus less, compared to HCs, suggesting increased self-focus among women with BN whilst comparing themselves to a 'slim ideal'. In these BN patients, exposure to food and body image stimuli increased self-reported levels of anxiety, but not craving.

Conclusions: Our findings suggest that women with BN differ from HCs in the way they process body image, but not in the way they process food stimuli.

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Related in: MedlinePlus

Right insula increased activation in the right insula (BA13; x = 36.1; y = -18.5; z = -16.5) in people with bulimia nervosa when self-schematic processing of pictures of thin women, compared to healthy controls. Contrast with low level baseline.
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Figure 2: Right insula increased activation in the right insula (BA13; x = 36.1; y = -18.5; z = -16.5) in people with bulimia nervosa when self-schematic processing of pictures of thin women, compared to healthy controls. Contrast with low level baseline.

Mentions: The between-group comparison showed greater activation in the right insula (Figure 2) and in the anterior lobe of the cerebellum in people with BN compared to HCs; less activation than the HC group was observed in the right fusiform gyrus, left middle occipital cortex and the (bilateral) precuneus.


Brain responses to body image stimuli but not food are altered in women with bulimia nervosa.

Van den Eynde F, Giampietro V, Simmons A, Uher R, Andrew CM, Harvey PO, Campbell IC, Schmidt U - BMC Psychiatry (2013)

Right insula increased activation in the right insula (BA13; x = 36.1; y = -18.5; z = -16.5) in people with bulimia nervosa when self-schematic processing of pictures of thin women, compared to healthy controls. Contrast with low level baseline.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225677&req=5

Figure 2: Right insula increased activation in the right insula (BA13; x = 36.1; y = -18.5; z = -16.5) in people with bulimia nervosa when self-schematic processing of pictures of thin women, compared to healthy controls. Contrast with low level baseline.
Mentions: The between-group comparison showed greater activation in the right insula (Figure 2) and in the anterior lobe of the cerebellum in people with BN compared to HCs; less activation than the HC group was observed in the right fusiform gyrus, left middle occipital cortex and the (bilateral) precuneus.

Bottom Line: Brain activation patterns in response to food cues did not differ between women with and without BN.However, when evaluating themselves against images of slim women, BN patients engaged the insula more and the fusiform gyrus less, compared to HCs, suggesting increased self-focus among women with BN whilst comparing themselves to a 'slim ideal'.Our findings suggest that women with BN differ from HCs in the way they process body image, but not in the way they process food stimuli.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King's College London, London, UK. Frederique.vandeneynde@mcgill.ca.

ABSTRACT

Background: Research into the neural correlates of bulimia nervosa (BN) psychopathology remains limited.

Methods: In this functional magnetic resonance imaging study, 21 BN patients and 23 healthy controls (HCs) completed two paradigms: (1) processing of visual food stimuli and (2) comparing their own appearance with that of slim women. Participants also rated food craving and anxiety levels.

Results: Brain activation patterns in response to food cues did not differ between women with and without BN. However, when evaluating themselves against images of slim women, BN patients engaged the insula more and the fusiform gyrus less, compared to HCs, suggesting increased self-focus among women with BN whilst comparing themselves to a 'slim ideal'. In these BN patients, exposure to food and body image stimuli increased self-reported levels of anxiety, but not craving.

Conclusions: Our findings suggest that women with BN differ from HCs in the way they process body image, but not in the way they process food stimuli.

Show MeSH
Related in: MedlinePlus