Limits...
Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients.

Kopp B, Rösser N, Tabeling S, Stürenburg HJ, de Haan B, Karnath HO, Wessel K - BMC Neurol (2013)

Bottom Line: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score.Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9).These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cognitive Neurology, Technische Universität Braunschweig, Salzdahlumer Str, 90, Braunschweig 38126, Germany. k.wessel@klinikum-braunschweig.de.

ABSTRACT

Background: The Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.

Methods: We examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.

Results: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).

Conclusions: These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

Show MeSH

Related in: MedlinePlus

Anatomical results obtained from the voxel-based lesion-behavior mapping (A) on the FAB global composite score, (B) on the FAB conceptualization score, (C) on the FAB mental flexibility score, and (D) on the FAB inhibitory control score. The location of voxels for which the voxel-based lesion-behavior mapping indicated that the observed Lz surpassed zcrit is shown. See text for details. Numbers indicate MNI coordinates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4225667&req=5

Figure 3: Anatomical results obtained from the voxel-based lesion-behavior mapping (A) on the FAB global composite score, (B) on the FAB conceptualization score, (C) on the FAB mental flexibility score, and (D) on the FAB inhibitory control score. The location of voxels for which the voxel-based lesion-behavior mapping indicated that the observed Lz surpassed zcrit is shown. See text for details. Numbers indicate MNI coordinates.

Mentions: Figure 3A depicts the location of those voxels for which the voxel-based lesion-behavior analysis revealed a significant association between voxel damage and the FAB global composite score. This analysis revealed a small area around MNI coordinates X = 35, Y = 6, Z = 16, a sub-lobar gray matter coordinate within the anterior insula (BA13).


Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients.

Kopp B, Rösser N, Tabeling S, Stürenburg HJ, de Haan B, Karnath HO, Wessel K - BMC Neurol (2013)

Anatomical results obtained from the voxel-based lesion-behavior mapping (A) on the FAB global composite score, (B) on the FAB conceptualization score, (C) on the FAB mental flexibility score, and (D) on the FAB inhibitory control score. The location of voxels for which the voxel-based lesion-behavior mapping indicated that the observed Lz surpassed zcrit is shown. See text for details. Numbers indicate MNI coordinates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225667&req=5

Figure 3: Anatomical results obtained from the voxel-based lesion-behavior mapping (A) on the FAB global composite score, (B) on the FAB conceptualization score, (C) on the FAB mental flexibility score, and (D) on the FAB inhibitory control score. The location of voxels for which the voxel-based lesion-behavior mapping indicated that the observed Lz surpassed zcrit is shown. See text for details. Numbers indicate MNI coordinates.
Mentions: Figure 3A depicts the location of those voxels for which the voxel-based lesion-behavior analysis revealed a significant association between voxel damage and the FAB global composite score. This analysis revealed a small area around MNI coordinates X = 35, Y = 6, Z = 16, a sub-lobar gray matter coordinate within the anterior insula (BA13).

Bottom Line: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score.Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9).These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cognitive Neurology, Technische Universität Braunschweig, Salzdahlumer Str, 90, Braunschweig 38126, Germany. k.wessel@klinikum-braunschweig.de.

ABSTRACT

Background: The Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.

Methods: We examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.

Results: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).

Conclusions: These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

Show MeSH
Related in: MedlinePlus