Limits...
Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients.

Kopp B, Rösser N, Tabeling S, Stürenburg HJ, de Haan B, Karnath HO, Wessel K - BMC Neurol (2013)

Bottom Line: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score.Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9).These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cognitive Neurology, Technische Universität Braunschweig, Salzdahlumer Str, 90, Braunschweig 38126, Germany. k.wessel@klinikum-braunschweig.de.

ABSTRACT

Background: The Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.

Methods: We examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.

Results: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).

Conclusions: These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

Show MeSH

Related in: MedlinePlus

Overlay lesion plots of all thirty-one patients in MNI space. Eight axial slices. The number of overlapping lesions is illustrated by colour, from violet (N = 1) to red (N = 31). Maximum overlap occurred in the right frontal lobe. The area coloured light blue indicates overlapping lesions in twelve patients (39% lesion overlap). Numbers indicate MNI coordinates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4225667&req=5

Figure 1: Overlay lesion plots of all thirty-one patients in MNI space. Eight axial slices. The number of overlapping lesions is illustrated by colour, from violet (N = 1) to red (N = 31). Maximum overlap occurred in the right frontal lobe. The area coloured light blue indicates overlapping lesions in twelve patients (39% lesion overlap). Numbers indicate MNI coordinates.

Mentions: Figure 1 shows overlay lesion plots of all thirty-one patients in eight axial slices of a standard brain (i.e., in MNI space). Inspection of Figure 1 reveals that the maximum lesion overlap occurred in the right prefrontal cortex (PFC) where up to twelve patients showed overlapping lesions in single voxels.


Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients.

Kopp B, Rösser N, Tabeling S, Stürenburg HJ, de Haan B, Karnath HO, Wessel K - BMC Neurol (2013)

Overlay lesion plots of all thirty-one patients in MNI space. Eight axial slices. The number of overlapping lesions is illustrated by colour, from violet (N = 1) to red (N = 31). Maximum overlap occurred in the right frontal lobe. The area coloured light blue indicates overlapping lesions in twelve patients (39% lesion overlap). Numbers indicate MNI coordinates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225667&req=5

Figure 1: Overlay lesion plots of all thirty-one patients in MNI space. Eight axial slices. The number of overlapping lesions is illustrated by colour, from violet (N = 1) to red (N = 31). Maximum overlap occurred in the right frontal lobe. The area coloured light blue indicates overlapping lesions in twelve patients (39% lesion overlap). Numbers indicate MNI coordinates.
Mentions: Figure 1 shows overlay lesion plots of all thirty-one patients in eight axial slices of a standard brain (i.e., in MNI space). Inspection of Figure 1 reveals that the maximum lesion overlap occurred in the right prefrontal cortex (PFC) where up to twelve patients showed overlapping lesions in single voxels.

Bottom Line: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score.Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9).These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cognitive Neurology, Technische Universität Braunschweig, Salzdahlumer Str, 90, Braunschweig 38126, Germany. k.wessel@klinikum-braunschweig.de.

ABSTRACT

Background: The Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.

Methods: We examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.

Results: Voxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).

Conclusions: These findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

Show MeSH
Related in: MedlinePlus