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Kidney function in severely obese adolescents undergoing bariatric surgery.

Xiao N, Jenkins TM, Nehus E, Inge TH, Michalsky MP, Harmon CM, Helmrath MA, Brandt ML, Courcoulas A, Moxey-Mims M, Mitsnefes MM, Teen-LABS Consorti - Obesity (Silver Spring) (2014)

Bottom Line: Mean age and median body mass index (BMI) were 17.1 years and 50.5 kg/m(2) , respectively; 76% were females and 65% were non-Hispanic white race.In adjusted analyses, female gender and increasing ferritin levels were significantly associated with the presence of microalbuminuria/macroalbuminuria.Increasing BMI and homeostasis model assessment of insulin resistance values were significantly associated with lower eGFR.

View Article: PubMed Central - PubMed

Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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Related in: MedlinePlus

Scatterplot of HOMA-IR and eGFR, Teen-LABS subjects
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Figure 3: Scatterplot of HOMA-IR and eGFR, Teen-LABS subjects

Mentions: Table 3 displays crude and adjusted associations between clinical features and eGFR. Crude results indicate female gender, BMI, transferrin, serum albumin, and HOMA-IR were associated with eGFR (each p < 0.05). However, after adjustment, increasing BMI and HOMA-IR values were the only factors that were significantly associated with decreased eGFR (each p < 0.05). Analyses indicated that for each 10-unit increase in BMI, eGFR decreased by nearly 8 mL/min/1.73m2, while for each 1-unit increase in HOMA-IR, eGFR decreased by only 0.57 mL/min/1.73m2. Figures 2 and 3 show the inverse relationships of BMI and HOMA-IR with eGFR.


Kidney function in severely obese adolescents undergoing bariatric surgery.

Xiao N, Jenkins TM, Nehus E, Inge TH, Michalsky MP, Harmon CM, Helmrath MA, Brandt ML, Courcoulas A, Moxey-Mims M, Mitsnefes MM, Teen-LABS Consorti - Obesity (Silver Spring) (2014)

Scatterplot of HOMA-IR and eGFR, Teen-LABS subjects
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4225641&req=5

Figure 3: Scatterplot of HOMA-IR and eGFR, Teen-LABS subjects
Mentions: Table 3 displays crude and adjusted associations between clinical features and eGFR. Crude results indicate female gender, BMI, transferrin, serum albumin, and HOMA-IR were associated with eGFR (each p < 0.05). However, after adjustment, increasing BMI and HOMA-IR values were the only factors that were significantly associated with decreased eGFR (each p < 0.05). Analyses indicated that for each 10-unit increase in BMI, eGFR decreased by nearly 8 mL/min/1.73m2, while for each 1-unit increase in HOMA-IR, eGFR decreased by only 0.57 mL/min/1.73m2. Figures 2 and 3 show the inverse relationships of BMI and HOMA-IR with eGFR.

Bottom Line: Mean age and median body mass index (BMI) were 17.1 years and 50.5 kg/m(2) , respectively; 76% were females and 65% were non-Hispanic white race.In adjusted analyses, female gender and increasing ferritin levels were significantly associated with the presence of microalbuminuria/macroalbuminuria.Increasing BMI and homeostasis model assessment of insulin resistance values were significantly associated with lower eGFR.

View Article: PubMed Central - PubMed

Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Show MeSH
Related in: MedlinePlus