Kidney function in severely obese adolescents undergoing bariatric surgery.
Bottom Line: Mean age and median body mass index (BMI) were 17.1 years and 50.5 kg/m(2) , respectively; 76% were females and 65% were non-Hispanic white race.In adjusted analyses, female gender and increasing ferritin levels were significantly associated with the presence of microalbuminuria/macroalbuminuria.Increasing BMI and homeostasis model assessment of insulin resistance values were significantly associated with lower eGFR.
Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.Show MeSH
Related in: MedlinePlus
Mentions: Table 3 displays crude and adjusted associations between clinical features and eGFR. Crude results indicate female gender, BMI, transferrin, serum albumin, and HOMA-IR were associated with eGFR (each p < 0.05). However, after adjustment, increasing BMI and HOMA-IR values were the only factors that were significantly associated with decreased eGFR (each p < 0.05). Analyses indicated that for each 10-unit increase in BMI, eGFR decreased by nearly 8 mL/min/1.73m2, while for each 1-unit increase in HOMA-IR, eGFR decreased by only 0.57 mL/min/1.73m2. Figures 2 and 3 show the inverse relationships of BMI and HOMA-IR with eGFR.
Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.