Kidney function in severely obese adolescents undergoing bariatric surgery.
Bottom Line: Determine objective measures of kidney function and analyze factors associated with kidney dysfunction in severely obese adolescents undergoing weight loss surgery were described.A significant number of severely obese adolescents undergoing weight loss surgery have evidence of early kidney dysfunction.Longitudinal studies following weight loss surgery in these individuals are needed to determine whether these kidney abnormalities are reversible following weight loss therapy.
Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.Show MeSH
Related in: MedlinePlus
Mentions: Table 3 displays crude and adjusted associations between clinical features and eGFR. Crude results indicate female gender, BMI, transferrin, serum albumin, and HOMA-IR were associated with eGFR (each p < 0.05). However, after adjustment, increasing BMI and HOMA-IR values were the only factors that were significantly associated with decreased eGFR (each p < 0.05). Analyses indicated that for each 10-unit increase in BMI, eGFR decreased by nearly 8 mL/min/1.73m2, while for each 1-unit increase in HOMA-IR, eGFR decreased by only 0.57 mL/min/1.73m2. Figures 2 and 3 show the inverse relationships of BMI and HOMA-IR with eGFR.
Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.