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Kidney function in severely obese adolescents undergoing bariatric surgery.

Xiao N, Jenkins TM, Nehus E, Inge TH, Michalsky MP, Harmon CM, Helmrath MA, Brandt ML, Courcoulas A, Moxey-Mims M, Mitsnefes MM, Teen-LABS Consorti - Obesity (Silver Spring) (2014)

Bottom Line: Determine objective measures of kidney function and analyze factors associated with kidney dysfunction in severely obese adolescents undergoing weight loss surgery were described.A significant number of severely obese adolescents undergoing weight loss surgery have evidence of early kidney dysfunction.Longitudinal studies following weight loss surgery in these individuals are needed to determine whether these kidney abnormalities are reversible following weight loss therapy.

View Article: PubMed Central - PubMed

Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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Related in: MedlinePlus

The percentile distribution of cystatin C-based eGFR from the Teen-LABS cohort and from published NHANES data (reference 14)Cystatin C was measured using the same methodology in both Teen-LABS and NHANES (Dade Behring, Deerfield, Illinois).39
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Figure 1: The percentile distribution of cystatin C-based eGFR from the Teen-LABS cohort and from published NHANES data (reference 14)Cystatin C was measured using the same methodology in both Teen-LABS and NHANES (Dade Behring, Deerfield, Illinois).39

Mentions: The mean cystatin C-based eGFR was 107.6 ml/min/1.73m2. Most of the Teen-LABS participants (68.5%) had a normal eGFR (90–150 ml/min/1.73m2) However, 51 (21.4%) had an eGFR of 60–90 ml/min/1.73m2; 7 (3.0%) had an eGFR <60 ml/min/1.73m2; and 17 (7.1%) had an eGFR >150 ml/min/1.73m2. Percentile distribution of eGFR from the Teen-LABS cohort and from published NHANES data is shown in Figure 1. There were more subjects in low percentile and high percentile brackets in the Teen-LABS cohort than in the NHANES participants.14


Kidney function in severely obese adolescents undergoing bariatric surgery.

Xiao N, Jenkins TM, Nehus E, Inge TH, Michalsky MP, Harmon CM, Helmrath MA, Brandt ML, Courcoulas A, Moxey-Mims M, Mitsnefes MM, Teen-LABS Consorti - Obesity (Silver Spring) (2014)

The percentile distribution of cystatin C-based eGFR from the Teen-LABS cohort and from published NHANES data (reference 14)Cystatin C was measured using the same methodology in both Teen-LABS and NHANES (Dade Behring, Deerfield, Illinois).39
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225641&req=5

Figure 1: The percentile distribution of cystatin C-based eGFR from the Teen-LABS cohort and from published NHANES data (reference 14)Cystatin C was measured using the same methodology in both Teen-LABS and NHANES (Dade Behring, Deerfield, Illinois).39
Mentions: The mean cystatin C-based eGFR was 107.6 ml/min/1.73m2. Most of the Teen-LABS participants (68.5%) had a normal eGFR (90–150 ml/min/1.73m2) However, 51 (21.4%) had an eGFR of 60–90 ml/min/1.73m2; 7 (3.0%) had an eGFR <60 ml/min/1.73m2; and 17 (7.1%) had an eGFR >150 ml/min/1.73m2. Percentile distribution of eGFR from the Teen-LABS cohort and from published NHANES data is shown in Figure 1. There were more subjects in low percentile and high percentile brackets in the Teen-LABS cohort than in the NHANES participants.14

Bottom Line: Determine objective measures of kidney function and analyze factors associated with kidney dysfunction in severely obese adolescents undergoing weight loss surgery were described.A significant number of severely obese adolescents undergoing weight loss surgery have evidence of early kidney dysfunction.Longitudinal studies following weight loss surgery in these individuals are needed to determine whether these kidney abnormalities are reversible following weight loss therapy.

View Article: PubMed Central - PubMed

Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Show MeSH
Related in: MedlinePlus