Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.
Bottom Line: Also, the anti-carcinogenic effects of NSAIDs are incompletely understood.Homozygous carriers of the variant allele of rs6983267 (ca. 25% of the population) halved their risk for CRC by aspirin use compared to homozygous wildtype carriers who did not benefit from aspirin intake.Knowledge of underlying biological effects of NSAIDs in relation to CRC is scarce and the basis for stratifying the patients for preventive treatment is not yet available.
Affiliation: Organ Center, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Medical Department, Regional Hospital Viborg, Viborg, Denmark.Show MeSH
Related in: MedlinePlus
Mentions: A systematic review and meta-analysis were carried out according to the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement.21 PubMed was searched for various combinations of ‘NSAID’, ‘aspirin’, ‘colorectal cancer’, ‘snp(s)’, ‘gene variant’ and ‘polymorphisms’ resulting in 85 abstracts (December 2013). All studies suggesting that they presented original data on polymorphisms and NSAID interaction were retrieved (46 articles) and reviewed and all studies reporting original data on interaction between polymorphisms and NSAID use in relation to risk of CRC were included (seven prospective cohort studies14,15,17–20,22 and 21 case–control studies23–43). In addition, two studies were identified in the reference lists from found articles.44,45 Another study was identified by searching for related articles (January 2014).46 One study analysed two separate prospective cohorts46 and one case–control study included both a discovery and a validation cohort.27 Three studies were excluded due to small numbers of participants and missing data on NSAID use.25,44,45 Furthermore, previously unpublished data on interactions between NSAIDs and HMOX in relation to CRC from a published study was added.47 Figure 1 shows the search strategy. A new search (May 2014) identified no new studies in PubMed and one case–control study in Embase which was included in Table 2.48
Affiliation: Organ Center, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Medical Department, Regional Hospital Viborg, Viborg, Denmark.