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Protocol of the Australasian Malignant Pleural Effusion (AMPLE) trial: a multicentre randomised study comparing indwelling pleural catheter versus talc pleurodesis.

Fysh ET, Thomas R, Read CA, Kwan BC, Lam BC, Yap E, Horwood FC, Lee P, Piccolo F, Shrestha R, Garske LA, Lam DC, Rosenstengel A, Bint M, Murray K, Smith NA, Lee YC - BMJ Open (2014)

Bottom Line: Whether IPC management reduces time spent in hospital in the patients' remaining lifespan is unknown.Secondary end points include hospital days specific to pleural effusion management, adverse events, self-reported symptom and quality-of-life scores.The Sir Charles Gairdner Group Human Research Ethics Committee has approved the study as have the ethics boards of all the participating hospitals.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia School of Medicine & Pharmacology, University of Western Australia, Perth, Western Australia, Australia Lung Institute of Western Australia, Perth, Western Australia, Australia.

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Related in: MedlinePlus

Statistical analysis plan (IPC, indwelling pleural catheter).
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Related In: Results  -  Collection

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BMJOPEN2014006757F2: Statistical analysis plan (IPC, indwelling pleural catheter).

Mentions: All outcomes will be analysed for superiority. Superiority analyses will be two-sided and considered statistically significant at the 5% level (figure 2). Unless otherwise stated, all analyses will be adjusted for the minimisation variables described above. Mean imputation will be used during analyses to adjust for missing values of baseline variables.


Protocol of the Australasian Malignant Pleural Effusion (AMPLE) trial: a multicentre randomised study comparing indwelling pleural catheter versus talc pleurodesis.

Fysh ET, Thomas R, Read CA, Kwan BC, Lam BC, Yap E, Horwood FC, Lee P, Piccolo F, Shrestha R, Garske LA, Lam DC, Rosenstengel A, Bint M, Murray K, Smith NA, Lee YC - BMJ Open (2014)

Statistical analysis plan (IPC, indwelling pleural catheter).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225240&req=5

BMJOPEN2014006757F2: Statistical analysis plan (IPC, indwelling pleural catheter).
Mentions: All outcomes will be analysed for superiority. Superiority analyses will be two-sided and considered statistically significant at the 5% level (figure 2). Unless otherwise stated, all analyses will be adjusted for the minimisation variables described above. Mean imputation will be used during analyses to adjust for missing values of baseline variables.

Bottom Line: Whether IPC management reduces time spent in hospital in the patients' remaining lifespan is unknown.Secondary end points include hospital days specific to pleural effusion management, adverse events, self-reported symptom and quality-of-life scores.The Sir Charles Gairdner Group Human Research Ethics Committee has approved the study as have the ethics boards of all the participating hospitals.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia School of Medicine & Pharmacology, University of Western Australia, Perth, Western Australia, Australia Lung Institute of Western Australia, Perth, Western Australia, Australia.

Show MeSH
Related in: MedlinePlus