Kaplan-Meier survival curves for 22q11Ds patients with

Case fatality rate and associated factors in patients with 22q11 microdeletion syndrome: a retrospective cohort study. Repetto GM, Guzmán ML, Delgado I, Loyola H, Palomares M, Lay-Son G, Vial C, Benavides F, Espinoza K, Alvarez P - BMJ Open (2014) Bottom Line: Case fatality rate was calculated and compared with national vital statistics.Fatality rate and associated factors. 59 of 419 patients (14.1%) died during the study period at a median of 3.4 months (range 0 to 32 years of age).These observations indicate a need to identify patients who may require specific perioperative management to improve survival. View Article: PubMed Central - PubMed Affiliation: Facultad de Medicina, Center for Genetics and Genomics, Clinica Alemana Universidad del Desarrollo, Santiago, Chile Hospital Padre Hurtado, Santiago, Chile. Show MeSH Major 22q11 Deletion Syndrome/mortality* Minor Adolescent Adult Child Child, Preschool Chile Cohort Studies Female Humans Infant Male Middle Aged Retrospective Studies Young Adult Related in: MedlinePlus	© Copyright Policy - open-access Related In: Results - Collection License Show All Figures getmorefigures.php?uid=PMC4225234&req=5 BMJOPEN2014005041F1: Kaplan-Meier survival curves for 22q11Ds patients with or without congenital heart disease (CHD). Mentions: Information about cardiac anatomy was available for 366 patients, corresponding to 87% of the total participants and 88.5% of the deceased. Of the 366 patients for whom cardiac anatomy information was available, 233 (63.7%) had a CHD, and 133 (36.3%) had a structurally normal heart and great vessels according to echocardiogram. The presence of cardiac anomalies was significantly associated with mortality; 46 patients with CHD (19.7% of all patients with CHD) and 6 patients without (4.5% of all patients without CHD) died during the study period (OR 5.27; 95% CI 2.06 to 13.99; p<0.0001; table 2). Figure 1 compares Kaplan-Meier survival curves for the patients with and without CHD. The two patients who died after 2 years of age did not have CHD.

Case fatality rate and associated factors in patients with 22q11 microdeletion syndrome: a retrospective cohort study.

Repetto GM, Guzmán ML, Delgado I, Loyola H, Palomares M, Lay-Son G, Vial C, Benavides F, Espinoza K, Alvarez P - BMJ Open (2014)

Bottom Line: Case fatality rate was calculated and compared with national vital statistics.Fatality rate and associated factors. 59 of 419 patients (14.1%) died during the study period at a median of 3.4 months (range 0 to 32 years of age).These observations indicate a need to identify patients who may require specific perioperative management to improve survival.

View Article: PubMed Central - PubMed

Affiliation: Facultad de Medicina, Center for Genetics and Genomics, Clinica Alemana Universidad del Desarrollo, Santiago, Chile Hospital Padre Hurtado, Santiago, Chile.

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Related in: MedlinePlus

Kaplan-Meier survival curves for 22q11Ds patients with or without congenital heart disease (CHD).

Related In: Results - Collection

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BMJOPEN2014005041F1: Kaplan-Meier survival curves for 22q11Ds patients with or without congenital heart disease (CHD).

Mentions: Information about cardiac anatomy was available for 366 patients, corresponding to 87% of the total participants and 88.5% of the deceased. Of the 366 patients for whom cardiac anatomy information was available, 233 (63.7%) had a CHD, and 133 (36.3%) had a structurally normal heart and great vessels according to echocardiogram. The presence of cardiac anomalies was significantly associated with mortality; 46 patients with CHD (19.7% of all patients with CHD) and 6 patients without (4.5% of all patients without CHD) died during the study period (OR 5.27; 95% CI 2.06 to 13.99; p<0.0001; table 2). Figure 1 compares Kaplan-Meier survival curves for the patients with and without CHD. The two patients who died after 2 years of age did not have CHD.