Fruit and vegetable intake and risk of type 2 diabetes mellitus: meta-analysis of prospective cohort studies.
Bottom Line: Studies published before February 2014 identified through electronic searches using PubMed and Embase.The combined estimates showed no significant benefits of increasing the consumption of fruit and vegetables combined.Higher fruit or green leafy vegetables intake is associated with a significantly reduced risk of type 2 diabetes.
Affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.Show MeSH
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Mentions: Seven comparisons from six studies reported an association between GLV intake and risk of T2D, with 19 139 T2D outcomes and 251 235 participants. Overall, GLV intake was inversely associated with risk (relative risk 0.87, 95% CI 0.81 to 0.93; figure 5). No significant heterogeneity was detected among studies (p=0.496, I2=0%). Additionally, we did not observe evidence of substantial publication bias (Begg and Egger regression tests, p=0.133 and p=0.101, respectively; see online supplementary table B in appendix 1). Among seven comparisons, only three comparisons were eligible for the trend estimation. Using a restricted cubic splines model, we found a significant curvilinear association (p=0.036 for non-linearity, figure 6). Dose–response analysis indicated that a 0.2 serving/day increment of GLV intake was associated with a 13% lower risk of T2D (relative risk 0.87, 95% CI 0.76 to 0.99, I2=20.9%; see online supplementary figure G in appendix 2). No publication bias was observed (p=0.282).
Affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.