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Socio-demographic and clinical profile of immuno-histochemically confirmed breast cancer in a resource limited country.

Rahman GA, Olatoke SA, Agodirin SO, Adeniji KA - Pan Afr Med J (2014)

Bottom Line: Most of the cases were estrogen receptor negative with majority of them having basal-like subtype.Most of the patients in this study were not only young but presented with locally advanced disease.Population screening, adequate health education, improved accessibility and availability of heath care will go a long way to improve the outcome of these patients.

View Article: PubMed Central - PubMed

Affiliation: General Surgery Division, Department of Surgery, University of Ilorin Teaching Hospital Ilorin, Ilorin, Nigeria.

ABSTRACT

Introduction: Breast cancer is the most common cancer in females. It is the most common cause of cancer-related death among women with fatality rates highest in low-income countries. The aim of this study is to determine the socio-demographic and clinical profile of patients with immunohistochemically confirmed breast cancer in a Nigerian tertiary health institution.

Methods: Patients with immunohistochemically confirmed breast cancer were reviewed. The information retrieved was entered into a proforma designed for the purpose of the study. Data was analysed using SPSS version 18.0.

Results: The peak incidence of age at presentation was in the 5th decade. More than 50% of the patients were premenopausal and perimenopausal at presentation. Only 11% of the patients presented with breast lumps less than 2 cm in size. Women in the age group 50-59 years are more likely to present with larger breast lumps than women in other groups. More than 50% had clinically palpable lymph node at presentation. Mastectomy (simple mastectomy and modified radical mastectomy) and adjuvant chemotherapy were the main form of treatment. Most of the cases were estrogen receptor negative with majority of them having basal-like subtype.

Conclusion: Most of the patients in this study were not only young but presented with locally advanced disease. Population screening, adequate health education, improved accessibility and availability of heath care will go a long way to improve the outcome of these patients.

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Relationship between surgical treatment and subtype of breast cancer (n = 82)
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Figure 0006: Relationship between surgical treatment and subtype of breast cancer (n = 82)

Mentions: The commonest forms of surgical treatment were simple (Total) mastectomy 39 (47.6%) and modified radical mastectomy (MRM) 45.1%. Seventy-six (92.7%) patients had adjuvant chemotherapy with the use of Cyclophosphamide, Methotrexate and 5-Fluorouracil (CMF) in 53.7% of the patients and Antracycline based and Taxane based in 42.7% and 2.4% respectively. A patient refused chemotherapy as adjuvant. Figure 2 shows menopausal status versus size of breast lump at presentation while Figure 3 shows the relationship between menopausal status of patients and the type of surgical treatment given. Basal subtype is the dominant subtype in this study with the highest figures in the 5th and 6th decades of life (Figure 4). Figure 5 shows the relationship between menopausal status and the subtypes of breast cancer. Majority of the patients who had modified radical mastectomy had basal subtype while patients who had simple mastectomy had more of unclassified subtype of breast cancer (Figure 6).


Socio-demographic and clinical profile of immuno-histochemically confirmed breast cancer in a resource limited country.

Rahman GA, Olatoke SA, Agodirin SO, Adeniji KA - Pan Afr Med J (2014)

Relationship between surgical treatment and subtype of breast cancer (n = 82)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225148&req=5

Figure 0006: Relationship between surgical treatment and subtype of breast cancer (n = 82)
Mentions: The commonest forms of surgical treatment were simple (Total) mastectomy 39 (47.6%) and modified radical mastectomy (MRM) 45.1%. Seventy-six (92.7%) patients had adjuvant chemotherapy with the use of Cyclophosphamide, Methotrexate and 5-Fluorouracil (CMF) in 53.7% of the patients and Antracycline based and Taxane based in 42.7% and 2.4% respectively. A patient refused chemotherapy as adjuvant. Figure 2 shows menopausal status versus size of breast lump at presentation while Figure 3 shows the relationship between menopausal status of patients and the type of surgical treatment given. Basal subtype is the dominant subtype in this study with the highest figures in the 5th and 6th decades of life (Figure 4). Figure 5 shows the relationship between menopausal status and the subtypes of breast cancer. Majority of the patients who had modified radical mastectomy had basal subtype while patients who had simple mastectomy had more of unclassified subtype of breast cancer (Figure 6).

Bottom Line: Most of the cases were estrogen receptor negative with majority of them having basal-like subtype.Most of the patients in this study were not only young but presented with locally advanced disease.Population screening, adequate health education, improved accessibility and availability of heath care will go a long way to improve the outcome of these patients.

View Article: PubMed Central - PubMed

Affiliation: General Surgery Division, Department of Surgery, University of Ilorin Teaching Hospital Ilorin, Ilorin, Nigeria.

ABSTRACT

Introduction: Breast cancer is the most common cancer in females. It is the most common cause of cancer-related death among women with fatality rates highest in low-income countries. The aim of this study is to determine the socio-demographic and clinical profile of patients with immunohistochemically confirmed breast cancer in a Nigerian tertiary health institution.

Methods: Patients with immunohistochemically confirmed breast cancer were reviewed. The information retrieved was entered into a proforma designed for the purpose of the study. Data was analysed using SPSS version 18.0.

Results: The peak incidence of age at presentation was in the 5th decade. More than 50% of the patients were premenopausal and perimenopausal at presentation. Only 11% of the patients presented with breast lumps less than 2 cm in size. Women in the age group 50-59 years are more likely to present with larger breast lumps than women in other groups. More than 50% had clinically palpable lymph node at presentation. Mastectomy (simple mastectomy and modified radical mastectomy) and adjuvant chemotherapy were the main form of treatment. Most of the cases were estrogen receptor negative with majority of them having basal-like subtype.

Conclusion: Most of the patients in this study were not only young but presented with locally advanced disease. Population screening, adequate health education, improved accessibility and availability of heath care will go a long way to improve the outcome of these patients.

Show MeSH
Related in: MedlinePlus