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Traumatic brain injury has not prominent effects on cardiopulmonary indices of rat after 24 hours: hemodynamic, histopathology, and biochemical evidence.

Najafipour H, Siahposht Khachaki A, Khaksari M, Shahouzehi B, Joukar S, Poursalehi HR - Iran. Biomed. J. (2014)

Bottom Line: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI.Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours.If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. najafipourh@kmu.ac.ir.

ABSTRACT

Background: Accidents are the second reason for mortality and morbidity in Iran. Among them, brain injuries are the most important damage. Clarification of the effects of brain injuries on different body systems will help physicians to prioritize their treatment strategies. In this study, the effect of pure brain trauma on the cardiovascular system and lungs 24 hours post trauma was assessed.

Methods: Male Wistar rats (n = 32) were divided into sham control and traumatic brain injury (TBI) groups. In TBI animals, under deep anesthesia, a blow to the head was induced by the fall of a 450 g weight from 2 m height. Twenty four hours later, heart electrocardiogram and functional indices, cardiac troponin I, IL-6, TNF-, IL-I in tissue and serum, and the histopathology of heart and lung were assessed.

Results: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI. Indices of impulse conduction velocity in atrium (P wave duration and P-R interval) were significantly longer in the TBI group.

Conclusion: Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours. If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

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Heart and lung histopathology of study groups. A sample microscopic slide of one animal of sham group heart (a), TBI group heart (b), sham group lung (c), and TBI group lung (d). There is no sign of abnormality in heart and lung in either of animals after 24 hours of head injury. hematoxylin and eosin staining (magnification 400×).
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Figure 2: Heart and lung histopathology of study groups. A sample microscopic slide of one animal of sham group heart (a), TBI group heart (b), sham group lung (c), and TBI group lung (d). There is no sign of abnormality in heart and lung in either of animals after 24 hours of head injury. hematoxylin and eosin staining (magnification 400×).

Mentions: Histopathology. A sample of heart and lung pathologic assessment of test and sham groups is shown in Figure 1. Except for a little vascular congestion in heart tissue (without tissue injury) and hyperaeration in lung of TBI group, there were no important pathologic findings 24 hours after TBI. The total pathologic score for both groups was 0.0 ± 0.0 and no signs of abnormality in heart or lung sections were seen in either of the animals.


Traumatic brain injury has not prominent effects on cardiopulmonary indices of rat after 24 hours: hemodynamic, histopathology, and biochemical evidence.

Najafipour H, Siahposht Khachaki A, Khaksari M, Shahouzehi B, Joukar S, Poursalehi HR - Iran. Biomed. J. (2014)

Heart and lung histopathology of study groups. A sample microscopic slide of one animal of sham group heart (a), TBI group heart (b), sham group lung (c), and TBI group lung (d). There is no sign of abnormality in heart and lung in either of animals after 24 hours of head injury. hematoxylin and eosin staining (magnification 400×).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225062&req=5

Figure 2: Heart and lung histopathology of study groups. A sample microscopic slide of one animal of sham group heart (a), TBI group heart (b), sham group lung (c), and TBI group lung (d). There is no sign of abnormality in heart and lung in either of animals after 24 hours of head injury. hematoxylin and eosin staining (magnification 400×).
Mentions: Histopathology. A sample of heart and lung pathologic assessment of test and sham groups is shown in Figure 1. Except for a little vascular congestion in heart tissue (without tissue injury) and hyperaeration in lung of TBI group, there were no important pathologic findings 24 hours after TBI. The total pathologic score for both groups was 0.0 ± 0.0 and no signs of abnormality in heart or lung sections were seen in either of the animals.

Bottom Line: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI.Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours.If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. najafipourh@kmu.ac.ir.

ABSTRACT

Background: Accidents are the second reason for mortality and morbidity in Iran. Among them, brain injuries are the most important damage. Clarification of the effects of brain injuries on different body systems will help physicians to prioritize their treatment strategies. In this study, the effect of pure brain trauma on the cardiovascular system and lungs 24 hours post trauma was assessed.

Methods: Male Wistar rats (n = 32) were divided into sham control and traumatic brain injury (TBI) groups. In TBI animals, under deep anesthesia, a blow to the head was induced by the fall of a 450 g weight from 2 m height. Twenty four hours later, heart electrocardiogram and functional indices, cardiac troponin I, IL-6, TNF-, IL-I in tissue and serum, and the histopathology of heart and lung were assessed.

Results: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI. Indices of impulse conduction velocity in atrium (P wave duration and P-R interval) were significantly longer in the TBI group.

Conclusion: Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours. If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

Show MeSH
Related in: MedlinePlus