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Traumatic brain injury has not prominent effects on cardiopulmonary indices of rat after 24 hours: hemodynamic, histopathology, and biochemical evidence.

Najafipour H, Siahposht Khachaki A, Khaksari M, Shahouzehi B, Joukar S, Poursalehi HR - Iran. Biomed. J. (2014)

Bottom Line: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI.Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours.If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. najafipourh@kmu.ac.ir.

ABSTRACT

Background: Accidents are the second reason for mortality and morbidity in Iran. Among them, brain injuries are the most important damage. Clarification of the effects of brain injuries on different body systems will help physicians to prioritize their treatment strategies. In this study, the effect of pure brain trauma on the cardiovascular system and lungs 24 hours post trauma was assessed.

Methods: Male Wistar rats (n = 32) were divided into sham control and traumatic brain injury (TBI) groups. In TBI animals, under deep anesthesia, a blow to the head was induced by the fall of a 450 g weight from 2 m height. Twenty four hours later, heart electrocardiogram and functional indices, cardiac troponin I, IL-6, TNF-, IL-I in tissue and serum, and the histopathology of heart and lung were assessed.

Results: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI. Indices of impulse conduction velocity in atrium (P wave duration and P-R interval) were significantly longer in the TBI group.

Conclusion: Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours. If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

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Electrical activity of the heart in study groups. A sample electrocardiography electrocardiogram (lead II) of one animal of sham (A) and TBI groups (B). Electrocardiograph speed 50 mm/s and sensitivity 0.1 mV/mm (each large division on the recording is equivalent to 0.1 seconds on horizontal axis and 0.2 mV on vertical axis). Longer P wave duration and P-R interval in TBI group are seen. An increase in heart rate (shorter R-R interval) is seen after TBI, but overall heart rate was not significantly different between the two groups (see Table 5).
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Figure 1: Electrical activity of the heart in study groups. A sample electrocardiography electrocardiogram (lead II) of one animal of sham (A) and TBI groups (B). Electrocardiograph speed 50 mm/s and sensitivity 0.1 mV/mm (each large division on the recording is equivalent to 0.1 seconds on horizontal axis and 0.2 mV on vertical axis). Longer P wave duration and P-R interval in TBI group are seen. An increase in heart rate (shorter R-R interval) is seen after TBI, but overall heart rate was not significantly different between the two groups (see Table 5).

Mentions: Heart electrical activity. In Figure 2, a sample ECG of TBI and sham groups, and in Table 5, the results of ECG indices in both groups 24 hours after TBI are shown. Statistical comparison showed no significant difference between the indices in the two groups, except for P wave duration and P-R interval, which were significantly longer (P<0.05) in the TBI group.


Traumatic brain injury has not prominent effects on cardiopulmonary indices of rat after 24 hours: hemodynamic, histopathology, and biochemical evidence.

Najafipour H, Siahposht Khachaki A, Khaksari M, Shahouzehi B, Joukar S, Poursalehi HR - Iran. Biomed. J. (2014)

Electrical activity of the heart in study groups. A sample electrocardiography electrocardiogram (lead II) of one animal of sham (A) and TBI groups (B). Electrocardiograph speed 50 mm/s and sensitivity 0.1 mV/mm (each large division on the recording is equivalent to 0.1 seconds on horizontal axis and 0.2 mV on vertical axis). Longer P wave duration and P-R interval in TBI group are seen. An increase in heart rate (shorter R-R interval) is seen after TBI, but overall heart rate was not significantly different between the two groups (see Table 5).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4225062&req=5

Figure 1: Electrical activity of the heart in study groups. A sample electrocardiography electrocardiogram (lead II) of one animal of sham (A) and TBI groups (B). Electrocardiograph speed 50 mm/s and sensitivity 0.1 mV/mm (each large division on the recording is equivalent to 0.1 seconds on horizontal axis and 0.2 mV on vertical axis). Longer P wave duration and P-R interval in TBI group are seen. An increase in heart rate (shorter R-R interval) is seen after TBI, but overall heart rate was not significantly different between the two groups (see Table 5).
Mentions: Heart electrical activity. In Figure 2, a sample ECG of TBI and sham groups, and in Table 5, the results of ECG indices in both groups 24 hours after TBI are shown. Statistical comparison showed no significant difference between the indices in the two groups, except for P wave duration and P-R interval, which were significantly longer (P<0.05) in the TBI group.

Bottom Line: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI.Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours.If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. najafipourh@kmu.ac.ir.

ABSTRACT

Background: Accidents are the second reason for mortality and morbidity in Iran. Among them, brain injuries are the most important damage. Clarification of the effects of brain injuries on different body systems will help physicians to prioritize their treatment strategies. In this study, the effect of pure brain trauma on the cardiovascular system and lungs 24 hours post trauma was assessed.

Methods: Male Wistar rats (n = 32) were divided into sham control and traumatic brain injury (TBI) groups. In TBI animals, under deep anesthesia, a blow to the head was induced by the fall of a 450 g weight from 2 m height. Twenty four hours later, heart electrocardiogram and functional indices, cardiac troponin I, IL-6, TNF-, IL-I in tissue and serum, and the histopathology of heart and lung were assessed.

Results: The results showed that none of the functional, biochemical, inflammatory, and histopathology indices was statistically different between the two groups at 24 hours post TBI. Indices of impulse conduction velocity in atrium (P wave duration and P-R interval) were significantly longer in the TBI group.

Conclusion: Overall, no important functional and histopathologic disturbances were found in heart and lung of TBI group after 24 hours. If the data is reproduced in human studies, the medical team could allocate their priority to treatment of brain disorders of the victim in the first 24 hours of pure TBI and postpone extensive assessment of heart and lung health indices to later time, thus reducing patient and health system expenditures.

Show MeSH
Related in: MedlinePlus