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Low coherence interferometry approach for aiding fine needle aspiration biopsies.

Chang EW, Gardecki J, Pitman M, Wilsterman EJ, Patel A, Tearney GJ, Iftimia N - J Biomed Opt (2014)

Bottom Line: We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation.Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.

ABSTRACT
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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Related in: MedlinePlus

Parameters from the training set. Statistically significant values are labeled for  values  (*);  (**); and  (***).
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f4: Parameters from the training set. Statistically significant values are labeled for values (*); (**); and (***).

Mentions: FigureĀ 4 summarizes the new set of six parameters and their statistical significance in tissue discrimination. It is noted that all of the parameters have statistical significance over at least one tissue type and only the SS/PD parameter is statistically significant among all tissue types.


Low coherence interferometry approach for aiding fine needle aspiration biopsies.

Chang EW, Gardecki J, Pitman M, Wilsterman EJ, Patel A, Tearney GJ, Iftimia N - J Biomed Opt (2014)

Parameters from the training set. Statistically significant values are labeled for  values  (*);  (**); and  (***).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4222708&req=5

f4: Parameters from the training set. Statistically significant values are labeled for values (*); (**); and (***).
Mentions: FigureĀ 4 summarizes the new set of six parameters and their statistical significance in tissue discrimination. It is noted that all of the parameters have statistical significance over at least one tissue type and only the SS/PD parameter is statistically significant among all tissue types.

Bottom Line: We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation.Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.

ABSTRACT
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

Show MeSH
Related in: MedlinePlus